United manager Jose Mourinho is bidding for his third major trophy in a little under two years with the club, having won the EFL Cup and the UEFA Europa League last season.
As for Chelsea, after losing last year's FA Cup final to Arsenal, they will have extra incentive to go one better this time around.
Date: Saturday, May 19
Time: 5:15 p.m. BST/12:15 p.m. ET
TV: BBC One, BT Sport 2 (UK), Fox (U.S.)
United finished second in the Premier League this season, having gained 12 more points than they did last year, scored 14 more goals and conceded one less.
However, after a disappointing UEFA Champions League exit at the hands of Sevilla in the round of 16 and ongoing concerns over their style of play, the perception of how successful their campaign has been could hinge on whether they pick up any silverware.
As Samuel Luckhurst of the Manchester Evening News noted, the Red Devils have offered frequent reminders throughout the year that they are not where they aspire to be:
They have fared quite well against their closest rivals, though, particularly in recent months, as football writer Liam Canning highlighted:
They also beat Tottenham Hotspur in the FA Cup semi-final, meaning they have beaten each of the Premier League's other top-six finishers since their 2-1 win over Chelsea on February 25.
It bodes well for United ahead of their clash with the Blues, who are also in need of a positive end to the season after they missed out on the UEFA Champions League places.
Their disappointing Premier League efforts culminated in a 3-0 defeat to Newcastle United on the final day.
ESPN FC's Liam Twomey was unimpressed:
While that result was rendered irrelevant in the context of the race for the top four because of Liverpool's 4-0 win over Brighton & Hove Albion, the performance was far from an ideal warm-up for a cup final.
With places in the starting lineup at Wembley on the line, it was an especially disappointing effort from Chelsea's players.
If they are to salvage the campaign and beat United to the trophy, they will need to significantly improve on that showing.