Per Gerry Dulac of the Pittsburgh Post-Gazette, the Steelers have already ruled out Smith-Schuster for Sunday's game.
Pittsburgh invested a second-round pick in Smith-Schuster following a standout career at USC that included 213 catches for 3,092 yards and 25 touchdowns across three seasons. He's turned in a fantastic rookie season thus far, ranking second on the Steelers with 568 receiving yards and five touchdowns.
Injuries are starting to become a concern for the first-year contributor, though. The 21-year-old California native missed time during training camp due to a concussion as well as ankle and knee problems. He entered the league's concussion protocol again leading up to Week 8.
With Smith-Schuster out for at least one week, Martavis Bryant should see the biggest uptick in targets. Eli Rogers and Darrius Heyward-Bey could also receive more playing time, though there are limited looks available since running back Le'Veon Bell is also a big factor in the passing game.
The early returns from Smith-Schuster have been promising, especially in terms of getting open in the red zone. Staying healthy will be a key factor as he attempts to solidify himself as a reliable weapon in the Steelers' aerial attack as they move closer to securing a playoff berth.