Week 10 NFL Picks: Latest Betting Odds, Vegas Spreads and Projections

Week 10 of the NFL season is chock-full of intriguing contests. Playoff-contending teams are beginning to emerge, and several key games on Sunday will have significant postseason implications.

We know what each team has to offer at this point in the season. The best offenses have made themselves known, and the best defenses remain consistent. However, due to some key injuries, plenty of facets must be taken into consideration when projecting a winner—especially when dealing with Vegas spreads.

So, what do oddsmakers think of these impending contests? Here's a look at the full slate of Week 10 games, their corresponding odds and a pick against the spread for each.

Matchup	Spread	Pick ATS
Cleveland Browns at Cincinnati Bengals	CIN -7	Bengals
Atlanta Falcons at Tampa Bay Buccaneers	TB -1.5	Falcons
Tennessee Titans at Baltimore Ravens	BAL -10	Titans
Pittsburgh Steelers at New York Jets	PIT -2.5	Steelers
San Francisco 49ers at New Orleans Saints	NO -2.5	Saints
Dallas Cowboys vs. Jacksonville Jaguars*	DAL -7.5	Jaguars
Miami Dolphins at Detroit Lions	DET -2	Lions
Kansas City Chiefs at Buffalo Bills	KC -2	Chiefs
Denver Broncos at Oakland Raiders	DEN -10.5	Broncos
New York Giants at Seattle Seahawks	SEA -7.5	Giants
St. Louis Rams at Arizona Cardinals	AZ -7.5	Cardinals
Chicago Bears at Green Bay Packers	GB -7.5	Packers
Carolina Panthers at Philadelphia Eagles	PHI -6	Panthers

All game lines courtesy of Odds Shark and current as of November 3.

Pick Analysis

San Francisco 49ers at New Orleans Saints (-2.5)

Mike McCarn/Associated Press

If someone were to tell you one of these teams were ranked within the top 10 in passing yards, rushing yards and run defense a couple weeks ago, you'd probably bet the farm it was the 49ers. Well, that's not the case anymore.

Drew Brees has found his form, ranking third in passing offense. Mark Ingram has been slicing through defenses lately, propelling the team to rank seventh in yards per game on the ground. Even the team's defense has begun to step up in the trenches, ranking 10th in the league against the run.

That's not a good sign for a San Francisco team that can't seem to find its identity on the offensive side of the ball.

For some reason, the 49ers have elected to go with a pass-happy offense. Quarterback Colin Kaepernick attempted 33 passes while the team rushed just 21 times in a 13-10 loss to the St. Louis Rams in Week 9. That kind of philosophy won't fly against the Saints.

Sure, San Francisco has a great defense, but Brees is simply on fire right now, and he has the advantage of playing at home. Here's a look at the team's current home streak following its last victory in the Mercedes-Benz Superdome, via NFL on ESPN:

The last time the 49ers faced a prolific passing offense on the road, they lost to Peyton Manning's Denver Broncos by a score of 42-17. That's not a good omen for this impending matchup.

Kansas City Chiefs (-2) at Buffalo Bills

Jamie Squire/Getty Images

This game does not set up very well for the Bills. Kansas City has been surging of late, and the Chiefs' defensive strengths could severely limit Buffalo's chances to get points on the board.

Quarterback Kyle Orton has been surprisingly efficient since being named the team's starter. He put up a very solid performance in Week 8 against the New York Jets, completing 10 of his 17 passing attempts for 238 yards and four touchdowns. Although, that came with a noticeable issue. Buffalo had no kind of running game.

With top running backs C.J. Spiller and Fred Jackson out of commission, Anthony Dixon and Bryce Brown were asked to share the workload. They didn't deliver, as the Bills averaged just 2.1 yards per carry.

That's not a good sign for Week 10, as Kansas City currently boasts the league's best pass defense, allowing an average of just 199.4 yards through the air per game. If Buffalo can't get its ground game going, the team may not have much of an offense at all.

Meanwhile, Alex Smith continues to quarterback the Chiefs to wins due to his high level of efficiency. Combined with a very solid ground attack featuring Jamaal Charles, Kansas City boasts a very well-balanced offense. ESPN's Christopher Harris noted the production the team is getting from all over the place:

Expect to see a low-scoring game, with the Chiefs pulling away due to an inefficient Bills offense.

Carolina Panthers (+6) at Philadelphia Eagles

Grant Halverson/Getty Images

This call may seem a little strange, but considering certain key injuries, the stars are aligning for the Panthers on Monday Night Football.

The Eagles emerged victorious against the Houston Texans in Week 9; however, the win came at the price of losing quarterback Nick Foles. The starting signal-caller will remain sidelined with a broken collarbone, according to NFL Network's Ian Rapoport:

Backup Mark Sanchez will step in against Carolina, and he's not exactly an upgrade at the quarterback position. While Sanchez did throw two touchdowns against Houston, he also threw two interceptions. That's not a good sign considering the Panthers were able to pressure Brees often in Week 9, sacking him four times while applying constant pressure.

While the Panthers offense hasn't been very strong of late, they'll have a chance to get back on track against an Eagles defense ranked 23rd against the pass and 20th against the run. Philadelphia struggled earlier in the season against the dual-threat Kaepernick, and Cam Newton could provide similar problems in Week 10.

This matchup will rest heavily on how well Sanchez can perform in his first start since 2012. Chances are he won't be good enough to earn a decisive victory, leading to a strong bet on the Panthers plus six points.