After coming so close in 2013, England once again will bid to break Wales' hold on the Six Nations this year, with their campaign beginning in French surroundings.
It's a mountain of a climb for Stuart Lancaster's side which, not abnormally, has taken on another experimental twist for the major European tournament.
Philippe Saint-Andre will be hoping Les Bleus have enough about them to gain redemption for last year's loss at Twickenham, as both teams' search for silverware gets off with a bang in Paris.
Date: Saturday, February 1
Time: 6 p.m. GMT/1 p.m. ET
Venue: Stade de France, Paris
Viewing Info: BBC One
Stream: BBC Sport website
Not for a long time have France and England gone up against one another under such unknown parameters, with Lancaster's experimentation this weekend perhaps at an all-time high.
Luther Burrell and Jack Nowell are both primed for their first international caps, while Jonny May earns just his second, starting on the left flank.
Meanwhile, Jules Plisson has been handed the French reins at fly-half, with Saint-Andre putting a deep amount of faith in the Stade Francais playmaker after not naming a natural No. 10 on his bench.
There's an encouraging sense of a fresh page being turned on this fixture; it merely remains a matter of who responds better to the fresh intake of faces.
Key Players to Watch
France: Mathieu Bastareaud
The centres will be the main attraction of this weekend's epic clash in the French capital. The experienced duo of Mathieu Bastareaud and Wesley Fofana take on England's pairing of Billy Twelvetrees and Burrell, who boast just five caps between them, all of which are accounted for by the latter.
Burrell's stopping power in the No. 13 jersey is one of his strongest attributes and undoubtedly one of the reasons why Lancaster has opted for the Northampton Saint ahead of other candidates this weekend.
But what happens when that stopping power meets one of the strongest midfield men in the game? Bastareaud has made it a habit of his to physically bully whoever might be lined up opposite him, and the Toulon centre could thrive if Burrell fails to put a brake on him.
In truth, the 25-year-old battering ram would have given a tough day's outing to anyone thrust into the English No. 13 shirt, but one can bet a hefty amount of ground coverage will be decided in this part of the field.
England: Jack Nowell
Replacing the England mainstay of Chris Ashton, Nowell is set for an almighty baptism through fire this Saturday, with his England debut not likely to have come under more difficult circumstances.
The Exeter Chiefs utility has been seen as a possible international star for some time now, and the journey to potentially doing just that starts at the Stade de France.
Charlie Morgan of Rugby World magazine says that Nowell will go on to earn more than 50 caps for England:
Maxime Medard has been in some fine form with Toulouse this term, while Nowell has failed to consistently produce the goods that many know are within his locker at all times.
That being said, with two such explosive characters set to do battle and neither one looking to yield a step to their counterpart, the 20-year-old England prodigy has a big test in backing up his coach's faith.