Fantasy Football Week 6 Rankings: Top Pickups After Latest Injuries

There are quite a few big-name NFL players who are currently dealing with injuries. Some of them won't be healthy enough to suit up for Week 6 action. And because of that, the fantasy football landscape will be impacted by their absences.

When a starting running back or wide receiver is out, it can greatly hurt a fantasy football manager's lineup. Unless they either have strong depth on their roster, or they can head to the waiver wire and pick up the player who will be getting an increased opportunity because of the injury situation.

With some key players likely to be out this weekend, here are updated Week 6 flex rankings and several potential top waiver-wire targets for fantasy managers to consider.

Top-25 Flex Rankings

Kevin Sabitus/Getty Images

TAMPA, FL - OCTOBER 9: A detail shot of a painted NFL shield logo on the field after an NFL football game between the Tampa Bay Buccaneers and the Atlanta Falcons at Raymond James Stadium on October 9, 2022 in Tampa, Florida. (Photo by Kevin Sabitus/Getty Images)

1. Los Angeles Rams WR Cooper Kupp (vs. CAR)

2. New York Giants RB Saquon Barkley (vs. BAL)

3. Los Angeles Chargers RB Austin Ekeler (vs. DEN)

4. Cleveland Browns RB Nick Chubb (vs. NE)

5. Carolina Panthers RB Christian McCaffrey (at LAR)

6. Indianapolis Colts RB Jonathan Taylor (vs. JAX)

7. Minnesota Vikings WR Justin Jefferson (at MIA)

8. Buffalo Bills WR Stefon Diggs (at KC)

9. Tampa Bay Buccaneers RB Leonard Fournette (at PIT)

10. New England Patriots RB Rhamondre Stevenson (at CLE)

11. New Orleans Saints RB Alvin Kamara (vs. CIN)

12. Minnesota Vikings RB Dalvin Cook (at MIA)

13. Cincinnati Bengals RB Joe Mixon (at NO)

14. San Francisco 49ers WR Deebo Samuel (at ATL)

15. Green Bay Packers RB Aaron Jones (vs. NYJ)

16. Cincinnati Bengals WR Ja'Marr Chase (at NO)

17. Tampa Bay Buccaneers WR Mike Evans (at PIT)

18. New York Jets RB Breece Hall (at GB)

19. Seattle Seahawks RB Kenneth Walker III (vs. ARI)

20. Kansas City Chiefs TE Travis Kelce (vs. BUF)

21. Philadelphia Eagles RB Miles Sanders (vs. DAL)

22. Denver Broncos RB Melvin Gordon III (at LAC)

23. Miami Dolphins RB Raheem Mostert (vs. MIN)

24. San Francisco 49ers RB Jeff Wilson Jr. (at ATL)

25. Los Angeles Chargers WR Mike Williams (vs. DEN)

Eno Benjamin, RB, Arizona Cardinals

AP Photo/Darryl Webb

Arizona Cardinals running back Eno Benjamin (26) during the second half of an NFL football game against the Kansas City Chiefs Sunday, Sept. 11, 2022, in Glendale, Ariz. (AP Photo/Darryl Webb)

If Eno Benjamin is still available in your league, pick him up immediately. Because the 23-year-old running back is in line for a big workload in the Cardinals' offense on Sunday.

Arizona is going to be without top RBs James Conner (ribs) and Darrel Williams (knee), who have both already been ruled out for its Week 6 road matchup against the Seattle Seahawks. That means the Cardinals will lean heavily on Benjamin in the contest.

Benjamin scored his first touchdown of the year in Arizona's Week 5 loss to the Philadelphia Eagles, as he matched a season high with 11 touches. He should get plenty more opportunities this week, which could lead to a big day for him.

It will help that the Cardinals are facing the Seahawks, who are allowing an NFL-high 170.2 rushing yards per game. So not only is Benjamin a must-add player, but he's a must-start player for Week 6.

Devin Duvernay, WR, Baltimore Ravens

AP Photo/Nick Wass

Baltimore Ravens wide receiver Devin Duvernay before an NFL football game against the Cincinnati Bengals, Sunday, Oct. 9, 2022, in Baltimore. (AP Photo/Nick Wass)

For the second week in a row, the Ravens will be without their top wide receiver, as Rashod Bateman will miss Sunday's game vs. the New York Giants because of a foot injury. Due to his absence, Devin Duvernay should again get plenty of passes thrown his way by quarterback Lamar Jackson.

Duvernay set season highs in catches (five) and targets (seven) in Baltimore's Week 5 win over the Cincinnati Bengals. He also had three rushing attempts while finishing with 78 total yards, his most in a game this year.

This Ravens-Giants matchup has the potential to be a competitive game, so both teams could be passing the ball late. So that should help Duvernay rack up some yardage and possibly get into the end zone for the first time since Week 3.

Expect Duvernay to have a solid performance that could feature a touchdown, putting him in flex consideration for fantasy managers this week.

Darius Slayton, WR, New York Giants

AP Photo/Seth Wenig

New York Giants wide receiver Darius Slayton (86) during the fourth quarter of an NFL football game against the Chicago Bears, Sunday, Oct. 2, 2022, in East Rutherford, N.J. (AP Photo/Seth Wenig)

The Giants' receiving corps continues to be banged up. Kenny Golladay (knee) and Kadarius Toney (hamstring) have already been ruled out for Week 6. And rookie Wan'Dale Robinson (knee) is questionable for New York's game against Baltimore.

Last week, Darius Slayton stepped up and had his best showing of the season. He had six catches for 79 yards in a win over the Green Bay Packers, after he entered the game with only one reception on the season.

Slayton should be heavily involved in the Giants' offense again this week, especially if Robinson is sidelined. Quarterback Daniel Jones will need to throw the ball to somebody, and Slayton has proven he can make an impact when given the opportunity.

Considering Slayton is available in nearly all fantasy leagues, he's a great last-minute pivot option if you're a manager waiting to see if an injured player is going to suit up this week.