2021 ESPY Play of the Year: Winner, Acceptance Speech and Twitter Reaction

The "Hail Murray" will now forever be immortalized in ESPYs lore.

Kyler Murray's game-winning heave to DeAndre Hopkins to lift the Arizona Cardinals to a victory over the Buffalo Bills was honored as the Best Play during the 2021 ESPY Awards on Saturday night.

Hopkins' improbable grab was also the Play of the Year for the NFL.

The Cardinals were involved in another Best Play finalist, D.K. Metcalf's incredible tackle to deny Budda Baker a pick-six.

Perhaps it's worth revisiting Murray's desperation throw to Hopkins in the end zone:

The Hail Mary isn't that uncommon in the NFL. Murray's ability to elude the pressure and release the ball on point while his momentum took him out of bounds was what set this apart.

Going off the NFL's Next Gen Stats, the likelihood of Murray hitting the target was only 16.9 percent. NFL Network's Ian Rapoport noted those was the third-lowest odds on a completed pass in Murray's young career.

Much like that fateful November evening, Hopkins sealed the deal at the ESPYs.

Hopkins and Murray figure to form a dynamic connection once again in 2021. The star wideout caught 115 passes for 1,407 yards and six touchdowns in his first year with the team, and he might benefit from the presence of A.J. Green and Rondale Moore since they'll inevitably occupy the defense's attention.

This time next year, the state of Arizona might be celebrating another Best Play ESPY, too.

Deandre Ayton's alley-oop to beat the Los Angeles Clippers in Game 2 of the Western Conference Finals came after ESPN rolled out all 16 nominees for Best Play. Surely the "Valley Oop" will take its place among the contenders in 2022.