Colts head coach Frank Reich told reporters about the diagnosis for Wentz, adding it was "too early" to tell if he'd be available on Sunday against the Tennessee Titans.
NFL Network's Ian Rapoport first reported on Monday that Wentz had injuries to both ankles.
Wentz told reporters after the game that he didn'tt believe his ankle is broken.
"Felt it right away, and it did not feel good," Wentz said, per The Athletic's Zak Keefer. "Tried to tape it up and do everything I could to finish the game. It's a bad feeling to not be able to finish the game in that situation. You kinda feel like you let the team down a little bit."
Any injury to Wentz is going to cause concern for multiple reasons. For one, the Colts made him their franchise quarterback when they traded for him this past offseason.
There is also his injury history, as the North Dakota State product has dealt with a number of physical concerns throughout his career and even missed the Philadelphia Eagles' run to the Super Bowl title during the 2017 campaign because of a torn ACL.
He also missed time in training camp and during the preseason this year because of a foot injury.
When healthy, Wentz has the potential to be one of the better quarterbacks in the league. He was an MVP candidate in 2017 before that injury and threw for 4,039 yards during the 2019 campaign while in Philadelphia.
If Wentz is sidelined for more than just Sunday following the latest setback, look for the Colts to turn to Eason again. The 2020 fourth-round draft pick entered the season having never attempted a pass in an NFL regular-season game and finished the 27-24 loss by going 2-of-5 for 15 yards and an interception.