Simmons has averaged 15.9 points, 7.8 assists and 8.0 rebounds throughout his fourth NBA season, appearing in 34 games for the 28-13 76ers.
He missed a pair of games in January with a knee injury and was then held out for two games in February, one because of left calf tightness and another for an illness.
The LSU product has been a major piece of Philadelphia's lineup since he was finally able to make his NBA debut after missing the 2016-17 campaign because of a foot fracture. The No. 1 overall pick was the league's Rookie of the Year in 2017-18 and earned All-Star nods in each of the next two seasons, even though he was limited in 2019-20 with a nerve impingement in his lower back and a knee injury that required surgery.
With Simmons out, the 76ers will likely turn to a combination of Tyrese Maxey, Furkan Korkmaz and Shake Milton off the bench.