Giants head coach Pat Shurmur told reporters Manning is "very likely" to start in place of Daniel Jones, who is in a walking boot because of a mild high-ankle sprain.
Jones suffered the injury in the first half of Sunday's 31-13 loss to the Green Bay Packers, but he played every offensive snap for New York.
In a conference call on Monday, Shurmur told reporters that Jones was dealing with "general game soreness" and wouldn't need to undergo X-rays or an MRI.
Jones also sounded optimistic about being able to play against the Eagles: "I think I'll be able to practice. It's sore, but that's typical for after the game. I think I'll be good to go."
Following an 0-2 start with Manning at quarterback, New York turned to Jones as its starter. The rookie first-round pick has thrown for 2,374 yards, 18 touchdowns and 11 interceptions in 11 games.
Manning hasn't appeared in a game for the Giants since Week 2 against the Buffalo Bills. He completed 62.9 percent of his attempts with two touchdowns and two interceptions in two games this season.
The Giants (2-10) are in last place in the NFC East and own the second-worst record in the NFL ahead of only the Cincinnati Bengals (1-11). They have lost five straight games against the Eagles dating back to the 2016 season.