Liverpool resume their Premier League campaign at Chelsea on Sunday after suffering their first loss of the season against Napoli in the UEFA Champions League, while the Blues hope to bounce back in Week 6 following a 1-0 home defeat to Valencia.
The Reds travel to Stamford Bridge looking to hand Blues head coach Frank Lampard a second straight loss at Stamford Bridge and potentially extend their own five-point lead at the top of the table.
Manchester City can temporarily close within two points of Liverpool if they beat Watford at home on Saturday. In the early kick-off, Leicester City host Tottenham Hotspur in a clash between Champions League hopefuls.
Manchester United beat Leicester 1-0 in Week 5 to end a three-match winless run, and they visit a West Ham United side who are unbeaten in four games on Sunday, when Arsenal will also host Aston Villa.
Southampton host Bournemouth in a clash between south-coast rivals on Friday, with both teams bringing an identical record to St. Mary's Stadium and level on seven points.
Week 6 Schedule, Predictions
Friday, September 20
Southampton 2-2 Bournemouth (Sky Sports, NBC Sports), 8 p.m. BST/3 p.m. ET
Saturday, September 21
Leicester City 2-2 Tottenham Hotspur (BT Sport, NBC Sports), 12:30 p.m. BST/7:30 a.m. ET
Manchester City 3-1 Watford (NBC Sports), 3 p.m. BST/10 a.m. ET
Burnley 2-1 Norwich City (NBC Sports), 3 p.m. BST/10 a.m. ET
Everton 1-0 Sheffield United (NBC Sports), 3 p.m. BST/10 a.m. ET
Newcastle United 1-1 Brighton & Hove Albion (Sky Sports, NBC Sports), 3 p.m. BST/10 a.m. ET
Sunday, September 22
West Ham United 2-2 Manchester United (Sky Sports, NBC Sports), 2 p.m. BST/9 a.m. ET
Crystal Palace 0-0 Wolverhampton Wanderers (NBC Sports), 2 p.m. BST/9 a.m. ET
Chelsea 1-3 Liverpool (Sky Sports, NBC Sports), 4:30 p.m. BST/11:30 a.m. ET
Arsenal 3-2 Aston Villa (NBC Sports), 4:30 p.m. BST/11:30 a.m. ET
Chelsea Seek Response Against Liverpool
A 1-0 loss at home to an out-of-form Valencia was far from the result Lampard will have sought in his Champions League debut as a head coach, especially with Liverpool being next to visit Stamford Bridge.
However, the former England international can still hope to become the second manager to defeat the Reds this week after Carlo Ancelotti set Napoli up for a 2-0 win in the opening match of their Champions League group.
Jurgen Klopp's side lost to the Serie A team last season before clinching the European crown, so perhaps two late goals for the Partenopei on their own turf isn't as damaging as it first appears, via BT Sport (UK only):
Dries Mertens converted a controversial 82nd-minute penalty to open the scoring, but Klopp told BT Sport's Des Kelly after the game that he didn't feel the spot-kick was justified:
Tuesday's result at the Stadio San Paolo was the second time in as many Champions League campaigns that Ancelotti has got the better of Klopp's side, and Lampard will have taken note.
The Chelsea boss was left frustrated in his Group H opener after Valencia striker Rodrigo scored the only goal at Stamford Bridge.
Substitute Ross Barkley missed a chance to equalise from the spot, which prompted questions regarding Chelsea's penalty-takers, via Tom Homewood of Yahoo Sports UK:
Willian spoke to reporters after the midweek defeat and said the players will be behind the former Everton midfielder as penalty-taker despite his miss, via Goal:
Liverpool beat Chelsea on penalties in the UEFA Super Cup in August, having drawn 2-2 after extra time, but Lampard will consider the league game against the Merseysiders more vital.
The Chelsea boss spoke to reporters following the loss to Valencia and said it was too early to tell whether Mason Mount would be fit to face Liverpool after the 20-year-old limped off with an ankle injury.
Blues striker Tammy Abraham is joint-top Premier League scorer with seven goals this season, but the imposing figures of Mohamed Salah and Sadio Mane have four apiece ahead of the trip to west London.
United Hit Form Ahead of West Ham Trip
Mason Greenwood scored his first senior goal for United on Thursday, when Solskjaer's side opened their UEFA Europa League campaign with a home 1-0 win over Astana.
Two penalties from Paul Pogba saw the Red Devils to a 2-1 win over West Ham when these teams met at Old Trafford in April, but the Frenchman remains injured ahead of Sunday's trip. He last featured in the 1-1 draw at Southampton on August 31.
Greenwood, 17, will hope to be involved following his maiden United goal, a coolly taken finish that took a much-changed lineup to a crucial three points at home (U.S. viewers only):
Solskjaer praised the youngster's breakthrough strike but highlighted a lack of precision in front of goal from his team:
West Ham are unbeaten in their last two home fixtures against United—they won 3-1 in September 2018 and drew 0-0 in east London four months prior.
Hammers manager Manuel Pellegrini has lost only three times in 12 encounters with United, per Transfermarkt, winning on four occasions and drawing five times.
His side are also unbeaten in five games across all competitions, and there's a chance United could be at risk of seeing their run of two wins end if they suffer any fatigue following their European commitments.
Solskjaer's men were without a win in three games prior to beating Leicester and Astana, though Sunday's guests are still seeking their first away win of the season (1-1 draws at Southampton and Wolverhampton Wanderers).
Pellegrini spoke to reporters on Friday and said Aaron Cresswell will stand in at left-back for the suspended Arthur Masuaku, who was sent off following two yellow cards in Monday's 0-0 draw at Aston Villa.