According to Jourdan Rodrigue of The Athletic, the plan is for Newton to get "some" reps in Monday's practice "if he continues to progress as positively as team doctors believe he will."
Newton was seen in a walking boot following the game and was diagnosed with a midfoot sprain.
Per Rodrigue, Panthers head coach Ron Rivera said the team is "cautiously optimistic" that Newton's injury will heal in time for the regular-season opener against the Los Angeles Rams on Sept. 8.
The 10-3 loss marked Newton's first preseason action. He finished 4-of-6 for 30 yards and was sacked twice.
Newton sat out the final two games of the 2018 regular season and underwent arthroscopic surgery on his throwing shoulder.
While Newton clearly struggled to throw the ball deep last season, he enjoyed one of his most efficient campaigns, completing a career-best 67.9 percent of his attempts for 3,395 yards and 24 touchdowns with 13 interceptions.
The 30-year-old veteran also rushed for 488 yards and four scores.
If Newton is not ready for the regular-season opener, Kyle Allen, Taylor Heinicke or rookie Will Grier will start.
None of them have played well enough to gain separation from the others during the preseason, but Allen and Heinicke each started a game last season. Allen threw for 228 yards and two touchdowns in a win over the New Orleans Saints, while Heinicke threw for 274 yards and a touchdown with three interceptions in a loss to the Atlanta Falcons.
Since Allen started the first two preseason games for Carolina, he may be the top candidate to fill in for Newton.