The England international was targeted on Twitter "within seconds" of seeing his spot-kick hit the post as the Red Devils slumped to their first defeat of the season, per Jake Polden at the Mirror.
Manchester United team-mate Paul Pogba was racially abused after missing a penalty against Wolverhampton Wanders on Monday. The club issued a statement condemning the racist tweets directed at their midfielder, per the Guardian's Jamie Jackson.
Manager Ole Gunnar Solskjaer said he was "deeply saddened" by the abuse directed at Pogba in his matchday programme notes for Saturday's fixture, as shared by Simon Stone at BBC Sport:
Simon Stone @sistoney67
OGS in @ManUtd prog: "Deeply saddened to start on a negative note. Must address + condemn disgusting racial abuse aimed towards Paul Pogba on Monday. There is no place in our society for this kind of behaviour. + has been encouraging to see it met with widespread condemnation."
Manchester United are set to meet with Twitter and Kick It Out in the wake of the abuse directed at Pogba, per BBC Sport.
Twitter said in a statement they will show the "the proactive work Twitter is doing to address online racist abuse towards certain footballers in the UK."
Rashford has already called on Twitter to put an end to the abuse:
Reading also offered their response after striker Yakou Meite was abused on social media:
England women's manager and former Manchester United defender Phil Neville has called on footballers to "boycott" social media to send a "powerful message" to companies, per BBC Sport.
Bleacher Report's Rob Blanchette said Manchester United should leave Twitter after Rashford became the latest player to be targeted:
Manchester United return to action against Southampton at St Mary's Stadium on Saturday, August 31.