The tale of the tape couldn't be more different, and the west London club's fight for survival has already begun in earnest.
Fulham have just one win from their 11 league matches despite becoming the first newly promoted team to spend more than £100 million on players in their first transfer window following promotion.
Date: Sunday, Nov. 11
Time: 12 p.m. (GMT), 7 a.m. (ET)
Odds: Liverpool: 11-100, Fulham: 25-1, draw: 10-1
TV: BT Sport 1 (UK), NBC Sports Live (U.S.)
Odds according to OddsShark.
Expectations were high for Fulham after they splashed the cash during the summer, but they have been miles off the pace in the top flight.
A trip to Liverpool is the last thing Fulham manager Slavisa Jokanovic needs, and morale appears low for the Craven Cottage side.
Jokanovic's position is in doubt after a poor start to life in the Premier League, and the Serb has firmly laid the blame at his players' door.
"We chose an ugly way to lose the game. You must be proud, competitive and fight at the last moment and make extra effort.
"We are right now not showing this quality or effort, we must wake up and when we lose the game we must know how we lost it; we cannot sell our skin so cheap.
"A few times before games I say my team is ready for the fight, but are not showing effort or ambition and we must change this.
"We must accept this situation and go outside our comfort zone, because this didn't bring us a good result."
After already conceding 29 goals in the league this season, Fulham must now face the Reds' world-class attacking line-up.
Despite a quiet start to the campaign, Mohamed Salah is showing glimpses of the player he was last season, when he was named the Premier League's player of the season.
Salah has seven goals in all competitions this term, but Sadio Mane has matched this haul to keep the Reds at the forefront of the chase for silverware.
Liverpool haven't been as potent as they were last year, but manager Jurgen Klopp now has a superior defence to recent versions.
Fulham have scored more goals than any other side in the bottom five, but they face an uphill task on Sunday.
Sky Sports pundit Paul Merson fears for the visiting team:
"They've got to get that balance right sooner rather than later, but you couldn't have asked for a worse game than a trip to Anfield. This is the time [when] managers under pressure worry about the clubs using the two-week period to get someone else in. Slavisa Jokanovic will be worried, especially after losing at Huddersfield.
"It's games like those that are Fulham's bread and butter because they are not expected to beat sides in the top six. They are in trouble."
At 25-1, Fulham are huge outsiders. If Liverpool suffer a European hangover after their 2-0 defeat to Red Star Belgrade, the Cottagers could use their freshness to steal a result.
Much was expected of Fulham starlet Ryan Sessegnon this season, and the England prospect could set alight his campaign if he produces the goods for his team on Sunday.