The match marks Los Blancos' first outing in 2018 and their return to action after La Liga embarked on its winter break on December 23.
Read on for a closer look at the contest, but first here are the viewing details:
Date: Thursday, January 4
Time: 8 p.m. GMT/3 p.m. ET
TV: beIN Sports USA
Live Stream: beIN Sports Connect (USA)
Real will be hoping their first match in 2018 goes significantly better than their last showing in 2017, in which they lost 3-0 to Barcelona at the Santiago Bernabeu.
It marked a disappointing end to what was an otherwise successful year for Los Blancos, and as ESPN FC's Dermot Corrigan noted, they need to turn things around:
Though fifth-placed Numancia are among the stronger sides in the Segunda Division, they represent a favourable draw for Madrid, particularly with the team needing to bounce back.
With Real trailing Barca by 14 points in La Liga, it would be somewhat surprising if the likes of Cristiano Ronaldo were to start given the level of opposition they face, though.
Manager Zinedine Zidane's ability to rotate his squad and continue to produce positive performances and results was one of the keys to their success last season, but it's something they've struggled with in this campaign.
Given the side will likely be relying on their squad players in this instance, it's important they put Real in a strong position in the tie and prove their worth as they have so often done in the past for Zidane.
Numancia will have to travel to the Bernabeu for the return leg on January 10—which does afford Los Blancos a little room for error on Thursday—but having to rectify a poor result is a hassle Real can do without as they look to reignite their season.