March Madness 2016 Bracket: Latest Picks, Odds Advice Before Thursday's Round 1

The First Four is in the books, and the first round of 64 teams is now officially set after Tuesday's and Wednesday's play-in games. 

Now it's time for the main event, the one that millions of college basketball fans have been waiting for. It's time to break out those brackets, reveal them to all of your peers and hope that this is the year you'll be the best of the best when it comes to predicting the sometimes unpredictable. 

Here is the updated bracket after the First Four games:

Wichita State and Florida Gulf Coast breezed to easy victories on Tuesday, while Michigan and Holy Cross punched their tickets to the first round on Wednesday. 

With the field set, there are plenty of games and prop bets for the betting man to take advantage of. The problem is knowing which ones to go with. 

Here are a couple of picks every college basketball fan should feel comfortable making during the NCAA tournament. All odds are courtesy of Odds Shark.

How many No. 1 Seeds will make the Final Four?

Over 1.5: 11-10

Under 1.5: 2-3

Pick: Take the under

Out of the four No. 1 seeds, only Kansas seems capable of making it out of the South Region and heading to the Final Four.

Kansas has enough firepower and an easy enough bracket to win the region. At worst, they'd have to play Maryland in the Sweet 16 and either Miami (FL) or Villanova in the Elite Eight. 

The same can't be said about the other three No. 1 seeds.

North Carolina, who in my book is the second-best top seed, might have to battle through teams like Kentucky and West Virginia to get out of the East Region. If the Wildcats don't wear the Tar Heels down in the Sweet 16, West Virginia's stifling defense could very well do the trick. 

Virginia, who shouldn't be a No. 1 seed, will lose to the team that should be at the top of the Midwest. No. 2 Michigan State had three more wins than Virginia and actually won its conference's postseason tournament. 

On the other hand, the Cavaliers didn't win the ACC regular-season or conference tournament titles. Both of those honors went to North Carolina. 

Oregon, which also surprised people at the top of the West Region, are certainly deserving of their No. 1 seed after going 28-6 with the third-toughest schedule in the nation and winning the Pac-12 title. 

The problem is that it will have to contend with the best scorer in the nation in No. 2 seed Oklahoma's Buddy Hield, who could single-handedly carry the Sooners to the Final Four. 

Recent history doesn't suggest that multiple No. 1 seeds will make the Final Four either. In the last six NCAA tournaments, only 2015 had more than one top seed. 

That's more than enough to keep me away from taking the over. 

Which seed will win the NCAA tournament?

Seed No.	Odds
1	6/5
2	3/1
3	7/1
4	7/1
5	9/1
6	18/1
7	25/1
8 or higher	20/1

Pick: Take the No. 1 Seed

Based on the advice given in the section above, this means that Kansas will take home the national championship. 

This is a team that scores over 80 points per game and allows less than 70. Playing in the Big 12 Conference, that's a good combination when looking for a team that's capable of winning a national championship. 

The Jayhawks have also already shown the kind of resiliency this season that's needed to make a deep run in the tournament:

Given the history of the NCAA tournament, though, taking a No. 1 seed is a safe bet. 

Since seeding began in 1979, a No. 1 seed has won the tournament 22 out of 37 times, which is obviously more than any other seed in the tournament. 

If you're looking to make the safe bet, this would be it. 

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Stats courtesy of ESPN.com.