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FILE - At left, in an Oct. 17, 2015, file photo, Alabama running back Derrick Henry (2) is chased by Texas A&M 's Myles Garrett  during the second half of an NCAA college football game in College Station, Texas. At right, in a Sept. 19, 2015, file photo, LSU running back Leonard Fournette (7)  runs past Auburn defensive back Blake Countess (24) on a touchdown run in the first half of an NCAA college football game in Baton Rouge, La. Perhaps out of respect _ if not reverence _ teammates of LSU's Leonard Fournette and Alabama's Derrick Henry seem to resist comparing the two running backs. Regardless, the similarities and differences of two of the nation's most powerful runners will come into focus when they lead their Top 10 teams onto the same field on Saturday night. (AP Photo/File)
FILE - At left, in an Oct. 17, 2015, file photo, Alabama running back Derrick Henry (2) is chased by Texas A&M 's Myles Garrett during the second half of an NCAA college football game in College Station, Texas. At right, in a Sept. 19, 2015, file photo, LSU running back Leonard Fournette (7) runs past Auburn defensive back Blake Countess (24) on a touchdown run in the first half of an NCAA college football game in Baton Rouge, La. Perhaps out of respect _ if not reverence _ teammates of LSU's Leonard Fournette and Alabama's Derrick Henry seem to resist comparing the two running backs. Regardless, the similarities and differences of two of the nation's most powerful runners will come into focus when they lead their Top 10 teams onto the same field on Saturday night. (AP Photo/File)Uncredited/Associated Press

College Football Picks Week 10: Odds and Spread Predictions for Top 25 Teams

Joe PantornoNov 6, 2015

Things are starting to heat up on the college football landscape, especially with the release of the first edition of the College Football Playoff rankings. 

It gives the college football world its first peek at which teams are the one's to beat in the quest for a national championship. Here are the current rankings:

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Clemson gets the top spot in the first postseason poll of the season, and the Tigers have quite the test this week. Taking on No. 16 Florida State, the Seminoles appear to be the last real roadblock of Clemson's campaign, as they finish the season with three manageable games. 

A big reason why they are on the cusp of making the College Football Playoff is because of their defense, which has been unbeatable, as ESPN.com's David Hale points out:

They aren't the only team within the top four that has a tough matchup during Week 10. Below is the upcoming schedule for the Top 25 teams of the College Football Playoff rankings:

Friday, Nov. 21
No. 22 Temple at SMU8 p.m.Temple -11.5Temple
Saturday, Nov. 22
Penn State at No. 21 Northwestern12 p.m.NW -2Penn State
Vanderbilt at No. 10 Florida12 p.m.Florida -19Florida
No. 5 Notre Dame at Pittsburgh12 p.m.ND -7.5Notre Dame
No. 11 Stanford at Colorado1 p.m.Stanford -16Stanford
No. 16 Florida St. at No. 1 Clemson3:30 p.m.Clemson -12Clemson
Arkansas at No. 18 Ole Miss3:30 p.m.Ole Miss -11Ole Miss
No. 9 Iowa at Indiana3:30 p.m.Iowa -8Iowa
Rutgers at No. 17 Michigan3:30 p.m.Michigan -21.5Michigan
No. 8 TCU at No. 14 Oklahoma St.3:30 p.m.TCU -5Oklahoma St.
Cincinnati at No. 25 Houston3:30 p.m.Houston -9Houston
No. 23 UCLA at Oregon State4:30 p.m.UCLA -15.5UCLA
Navy at No. 13 Memphis7 p.m.Memphis -8.5Memphis
Iowa State at No. 15 Oklahoma7 p.m.Oklahoma -26Oklahoma
No. 7 Michigan State at Nebraska7 p.m.MSU -4.5Michigan State
No. 12 Utah at Washington7:30 p.m.EvenUtah
Auburn at No. 19 Texas A&M7:30 p.m.A&M -8.5Texas A&M
No. 2 LSU at No. 4 Alabama8 p.m.Alabama -7LSU
Minnesota at No. 3 Ohio State8 p.m.OSU -23Ohio State

Game of the Week

No. 2 LSU at No. 4 Alabama

Sure, this could have been a stunt to get even more viewers considering there are plenty of undefeated teams that could take the No. 4 spot, but one-loss Alabama will be hosting No. 2 LSU in a game that is going to rock the CFP rankings in just the first week. 

But what a matchup this is going to be. LSU, now in the meat of their schedule, is about to take on three ranked SEC opponents in their last four games. If they somehow win out, they are a lock for the playoff, and might be considered the favorites. 

They have the right weapon in running back Leonard Fournette, who is having a historic season as SEC Network points out:

He will face his toughest test of a Heisman Trophy-worthy campaign in the Alabama defense, which is allowing just over 78 rushing yards per game this season. 

The problem is Alabama hasn't lost to LSU since 2011 and have quite a running back of their own in Derrick Henry, who Fournette has a lot of respect for, according to WAFB's Jacques Doucet:

If he is able to wear down the LSU defense and put some points on the board, the Alabama defense, which has allowed just over 16 points per game this season, could hold down the Tigers just enough. 

Granted, the pick might be different if this game was being played in Death Valley, but being the home team is sure to help out Alabama. 

Prediction: Alabama 23, LSU 17

Mitchell Headed to 1st Conference Finals 🔥

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