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COLLEGE STATION, TEXAS - OCTOBER 26: Garrett Nussmeier #13 of the LSU Tigers throws a pass in the second half against the Texas A&M Aggies at Kyle Field on October 26, 2024 in College Station, Texas. (Photo by Tim Warner/Getty Images)
COLLEGE STATION, TEXAS - OCTOBER 26: Garrett Nussmeier #13 of the LSU Tigers throws a pass in the second half against the Texas A&M Aggies at Kyle Field on October 26, 2024 in College Station, Texas. (Photo by Tim Warner/Getty Images)Tim Warner/Getty Images

College Football Picks Week 11: Top 25 Odds, Box Score Prediction, Rankings, Schedule

Joe TanseyNov 4, 2024

The Alabama Crimson Tide and LSU Tigers will put their College Football Playoff lives on the line in Week 11's marquee matchup.

Each team has two losses going into the primetime contest in Baton Rouge, and even though upsets happened in Week 10, it is difficult to see a three-loss team receiving an at-large berth into the CFB Playoff.

Both programs displayed their share of mistakes this season, which makes it hard to trust either one of them from a betting perspective.

One SEC team, though, has been a money maker as an underdog, and once again, the Vanderbilt Commodores are in that role against the South Carolina Gamecocks.

Diego Pavia and Co. have been one of the most profitable teams in 2024 and they have potential to add to the list of upset wins against the South Carolina Gamecocks.

Week 11 Top 25 Schedule and Odds

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MIAMI GARDENS, FL - NOVEMBER 02: Miami quarterback Cam Ward (1) looks to throw the ball Miami wide receiver Xavier Restrepo (not shown) for a touchdown during the college football game between the Duke Blue Devils and the University of Miami Hurricanes on November 2, 2024 at the Hard Rock Stadium in Miami Gardens, FL. (Photo by Doug Murray/Icon Sportswire via Getty Images)
MIAMI GARDENS, FL - NOVEMBER 02: Miami quarterback Cam Ward (1) looks to throw the ball Miami wide receiver Xavier Restrepo (not shown) for a touchdown during the college football game between the Duke Blue Devils and the University of Miami Hurricanes on November 2, 2024 at the Hard Rock Stadium in Miami Gardens, FL. (Photo by Doug Murray/Icon Sportswire via Getty Images)

Odds via DraftKings Sportsbook.

Saturday, November 9

Purdue at No. 3 Ohio State (-38) (Noon ET, Fox)

No. 4 Miami (-11) at Georgia Tech (Noon ET, ESPN)

Florida at No. 5 Texas (-21) (Noon ET, ABC)

No. 2 Georgia (-2.5) at No. 16 Ole Miss (3:30 p.m. ET, ABC)

Michigan at No. 8 Indiana (-14) (3:30 p.m. ET, CBS)

No. 17 Iowa State (-3) at Kansas (3:30 p.m. ET, FS1)

No. 18 Army (-5.5) at North Texas (3:30 p.m. ET, ESPN2)

No. 19 Clemson (-6.5) at Virginia Tech (3:30 p.m. ET, ESPN)

No. 21 Colorado (-3) at Texas Tech (4 p.m. ET, Fox)

South Carolina (-3.5) at No. 24 Vanderbilt (4:15 p.m. ET, SEC Network)

Maryland at No. 1 Oregon (-25) (7 p.m. ET, BTN)

Mississippi State at No. 7 Tennessee (-24) (7 p.m. ET, ESPN)

Florida State at No. 10 Notre Dame (-26) (7:30 p.m. ET, NBC)

No. 11 Alabama (-3) at No. 14 LSU (7:30 p.m. ET, ABC)

Washington at No. 6 Penn State (-13.5) (8 p.m. ET, Peacock)

Nevada at No. 12 Boise State (-25) (8 p.m. ET, Fox)

Virginia at No. 23 Pittsburgh (-7) (8 p.m. ET, ACC Network)

No. 9 BYU (-4) at Utah (10;15 p.m. ET, ESPN)

Utah State at No. 20 Washington State (-20.5) (10:30 p.m. ET, CW)

No. 11 Alabama at No. 14 LSU (+3)

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COLLEGE STATION, TX - OCTOBER 26: LSU Tigers quarterback Garrett Nussmeier (13) looks to throw downfield during the football game between the LSU Tigers and Texas A&M Aggies on October 26, 2024 at Kyle Field in College Station, Texas. (Photo by Ken Murray/Icon Sportswire via Getty Images)
COLLEGE STATION, TX - OCTOBER 26: LSU Tigers quarterback Garrett Nussmeier (13) looks to throw downfield during the football game between the LSU Tigers and Texas A&M Aggies on October 26, 2024 at Kyle Field in College Station, Texas. (Photo by Ken Murray/Icon Sportswire via Getty Images)

It's hard to throw full trust behind the two quarterbacks in the Alabama-LSU showdown.

Jalen Milroe threw six interceptions in the last five games, including two in the loss to the Tennessee Volunteers.

Garrett Nussmeier completely fell apart in the second half of LSU's loss to the Texas A&M Aggies.

LSU's defeat to A&M is fresher in the minds of college football fans since it happened two weeks ago. The Tigers were in control and then struggled to contain Marcel Reed and could not prevent turnovers from happening.

Alabama has been the dominant team in the rivalry, but that was under Nick Saban. Kalen DeBoer will be making his first trip to Baton Rouge with the Crimson Tide.

LSU won the last meeting on home soil in 2022 and it captured wins in two of the last three matchups with Alabama when both teams were ranked.

Both of Alabama's SEC losses have come on the road and LSU holds one of the best home-field advantages in the sport, especially at night.

The Tigers have the slightest of edges as the home side, but do not expect a blow out, especially if both quarterbacks play up to their potential and avoid mistakes.

South Carolina at No. 24 Vanderbilt (+3.5)

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AUBURN, ALABAMA - NOVEMBER 02: Quarterback Diego Pavia #2 of the Vanderbilt Commodores looks to throw a pass during the second half of their game against the Auburn Tigers at Jordan-Hare Stadium on November 02, 2024 in Auburn, Alabama. (Photo by Michael Chang/Getty Images)
AUBURN, ALABAMA - NOVEMBER 02: Quarterback Diego Pavia #2 of the Vanderbilt Commodores looks to throw a pass during the second half of their game against the Auburn Tigers at Jordan-Hare Stadium on November 02, 2024 in Auburn, Alabama. (Photo by Michael Chang/Getty Images)

Keep making Vanderbilt an underdog and we will keep betting on the Commodores.

Vanderbilt cashed as an outright underdog against Alabama, the Kentucky Wildcats and Auburn Tigers in SEC play. It also covered the spread versus the Missouri Tigers and Texas Longhorns.

Diego Pavia and Co. are simply undervalued by the oddsmakers and they have proved on a continuous basis that they should be trusted in that role.

South Carolina resides in a tough emotional spot in Week 11, as it has to hit the road after upsetting Texas A&M at home in Week 10.

The Gamecocks have been feisty in their own right in SEC play. They lost by a combined five points to Alabama and LSU.

However, it may be hard for South Carolina to contain Pavia, even with one of the better pass rushes in the SEC.

The Commodore should continue to embrace the underdog role, a spot they will be in to close out the regular season with LSU and Tennessee on the schedule after Week 11.

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No. 21 Colorado (-3) at Texas Tech

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BOULDER, CO - OCTOBER 26:  Jimmy Horn Jr. #5 of the Colorado Buffaloes runs after a catch in the first quarter against the Cincinnati Bearcats at Folsom Field on October 26, 2024 in Boulder, Colorado. (Photo by Dustin Bradford/Getty Images)
BOULDER, CO - OCTOBER 26: Jimmy Horn Jr. #5 of the Colorado Buffaloes runs after a catch in the first quarter against the Cincinnati Bearcats at Folsom Field on October 26, 2024 in Boulder, Colorado. (Photo by Dustin Bradford/Getty Images)

The Colorado Buffaloes are a major player in the CFB Playoff conversation.

Deion Sanders' team has a path to the Big 12 Championship Game after the Week 10 defeats suffered by the Iowa State Cyclones and Kansas State Wildcats.

The newfound motivation that the Buffaloes can seriously make the playoff should push them just a bit more against the Texas Tech Red Raiders.

Texas Tech exerted a ton of energy to upset Iowa State on the road in Week 10, and now it will be forced to get into a track meet with Colorado.

The Red Raiders' fast pace typically challenges defenses, but that might not be the case against a Colorado offense that also likes to push the ball down the field fast.

The over of 63 should be one of the best bets of the weekend because of the two strong passing offenses, but in the end, Colorado simply has the better talent and do not be surprised if Travis Hunter comes up with a few game-changing plays on defense to further his Heisman candidacy.

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Odds and lines subject to change. 21+ (18+ NH/WY). AZ/CO/CT/IL/IN/IA/LA/MI/NH/NJ/NY/OR/PA/TN/VA/WV/WY only. Eligibility restrictions apply. See draftkings.com/sportsbook for full terms and conditions.

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