When in form, Roger is unstoppable, winning the US Open five times in a row from 2004 to 2008.
However, this season he hasn't been at his best and hasn't won a single Grand Slam, having only appeared in one: his Rolland Garros lose against Rafa Nadal.
Will Roger Federer bounce back at Queens?
Start the slideshow to see who he'll have to beat if he's to win his first Grand Slam of the year at the US Open.
2011 ATP ranking: 56
2011 Record: 24-20
US Open seed: -
Odds to win 2011 US Open: 500:1
Odds Federer is eliminated: 20:1
In his round one match against Giraldo, Roger Federer should have no problem at all.
He's never played the Colombian before, but Andy Roddick had no trouble with him in Winston Sallem, winning 6-1 and 6-3.
Girlado's only won one Grand Slam match ever, so I expect Federer to win it easy in three sets.
2011 ATP ranking: 35
2011 Record: 24-19
US Open seed: -
Odds to win 2011 US Open: 300:1
Odds Federer is eliminated: 14:1
Bellucci should defeat the world's No. 95 Dudi Sela in his first match to go on to face Federer in Round 2.
If that happens, the left-handed Brazilian will be Roger's next rival, and a much harder opponent than Giraldo was in Round 1.
Belluci has already defeated Andy Murray and Thomas Berdych in Madrid this year, and he was No. 22 in the World after losing to Djokovic in the semifinal.
Expect Belluci to put up a fight but eventually lose to Federer in four sets.
Thomaz is good enough to push him to the fifth one, though.
2011 ATP ranking: 27
2011 Record: 30-17
US Open seed: 27
Odds to win 2011 US Open: 80:1
Odds Federer is eliminated: 7:1
Twenty-seventh-ranked Marin Cilic should have no trouble getting to this spot to face Federer.
Roger has never lost to Cilic, and defeated him in two sets by scores of 6-4 and 6-3 in Monte Carlo's clay court, where the Croatian is at his best.
Expect Roger to beat him easily and move on in three sets here.
2011 ATP ranking: 15
2011 Record: 34-18
US Open seed: 15
Odds to win 2011 US Open: 200:1
Odds Federer is eliminated: 13/2:1
If everything goes according to planned, Viktor Troicki should defeat Radek Stepanek (23) to face Federer here.
Troicki lost 6-2, 6-2 against Federer in the Qatar Open this year, and has never beaten the Swiss in two matches played.
Expect Roger to advance easily in this one, winning in three or four sets at the most.
2011 ATP ranking: 11
2011 Record: 33-16
US Open seed: 11
Odds to win 2011 US Open: 33:1
Odds Federer is eliminated: 10/3:1
I'm going with my first upset here, taking Tsonga over American Mardy Fish (8) in their first match ever against each other.
Tsonga got injured in Cincinnati, but I expect him to come on strong at Queens and face Federer in Round 4.
Against Federer Tsonga has won three and lost four, with one win each on hard court matches.
In the most recent game they played, Tsonga eliminated Roger in five sets at Wimbledon, defeating the Swiss 3-6, 6-7, 6-4, 6-4 and 6-4.
It has to be said that Tsonga seems particularly adept at beating Federer, so expect a very tough game here for Roger, and if he's to win it, he'll probably have to go five sets to do it.
If Mardy Fish is here though, it could be way easier for Roger, as he has beaten him six out of seven times they've played.
2011 ATP ranking: 1
2011 Record: 57-2
US Open seed: 1
Odds to win 2011 US Open: 6/5:1
Odds Federer is eliminated: 15/8:1
Djokovic time it is.
Odds-wise, this is where Roger's US Open should end.
However, if someone can beat Nole at Queens, it's Federer.
Career-wise Djokovic and Roger have a 13-9 record in favor of the Swiss, but this year, the world's No. 1 has won three out of four.
What about the loss?
It was the last time they met in Rolland Garros, where Federer stopped him in the semifinals winning in four sets by scores of 7-6, 6-3, 3-6 and 7-6.
So, if Djokovic isn't 100 percent percent healthy, the match could easily go Roger's way here.
Don't expect it to be easy by any means, though, as Nole is clearly the best tennis player in the world right now.
Nationality: Great Britain
2011 ATP ranking: 4
2011 Record: 34-10
US Open seed: 4
Odds to win 2011 US Open: 5:1
Odds Federer wins US Open: 9/2:1
Murray should top Nadal to play Federer in the US Open Final.
Roger is 5-7 against the Brit, who is also very solid when playing the Swiss.
Not as good as Nadal is, though, as he has beaten Federer in 17 occasions while losing only eight.
However if Roger is playing good enough to beat Djokovic in the semifinals, he should be on a good enough form to win it all against either in Queens.
The key, though, is beating Nole.
It's all downhill from there for Federer.
Follow Andrés Ehrli on Twitter! @ehrli