The match ended at 6-3, 7-5 for Federer as the world No. 3 advanced in just over 90 minutes.
As a result of the loss, two sportsbooks have lengthened Del Potro's odds in the futures market for the 2011 US Open. Stan James now have Delpo at 8/1 to win the title outright while Paddy Power have lengthed the Argentine's odds to 12/1.
But when you look at Del Potro's body of work since coming back from his wrist injury, what is there to suggest that he is anything but a 50/1 longshot to win the 2011 US Open?
Del Potro does not have any wins in 2011 over the best hard courters on tour. He did beat Soderling back in Miami at a time when the Swede was ranked fourth in the world, however Soderling is hardly a contender for the US Open title himself.
Del Potro's only significant highlights this season are two ATP titles, one at Estoril and one at Delray Beach.
The Estoril title was a clay court title and doesn't imply much, if anything at all, about success at Flushing Meadows. The Delray Beach title included a win over Mardy Fish and while that is a solid win, it's not exactly a victory over Rafael Nadal, Novak Djokovic or Roger Federer.
Those three players are the top three favorites for the US Open and if Del Potro was a serious challenger, even just to make the semifinals in New York, then he should have a win in 2011 against one of those players.
Del Potro is looking like a middle-seed in Flushing Meadows later this month and all anyone should be expecting of him is a third or fourth round appearance.
If he makes the quarters he will have overachieved as the 2009 champion is now a shadow of his former self.