It's been an up-and-down 2011 for Kim Clijsters. After finally cementing her name as "Aussie Kim" with her win in Melbourne at the start of the year, a succession of niggling injuries have prevented her from progressing in the other slams.
Now it looks like she may miss the chance to defend her title at Flushing Meadows at the end of the month after withdrawing from the Rogers Cup with an apparent stomach injury.
So if Clijsters doesn't make it, who could take that title?
If Clijsters isn't there, this year's other slam winners will be. Li Na had a disappointing spell during the start of the summer, but having had a break, she's back on the tour.
The plan was that she would be raring to go again, but at the Rogers Cup all she managed was a bye, a walkover, and a straight-sets defeat to Sam Stosur. She should do better at the big stage.
The Wimbledon champion had a week as disappointing as her French Open-winning counterpart: she struggled with the conditions in Canada to lose in straight sets to Andrea Petkovic.
With that powerful serve, though, she's likely to put in a decent performance in New York.
Maria Sharapova last won the US Open title in 2006. Just as she wanted to show everyone at Wimbledon that she's still at her best, she'll want to do the same at Flushing Meadows.
Though she may have lost in Toronto to Kazakhstani qualifier Galina Voskoboeva, by the time the tournament rolls around, she'll have had a lot more match practice.
Well, I thought this year's Wimbledon would be her best chance yet to pick up a Grand Slam title with all those big names either not showing up or exiting early, but it wasn't to be.
Maybe the world No. 1 can finally win that elusive title in New York.
She was knocked out of the Rogers Cup in the second round, losing to Roberta Vinci, which may not bode well. Wozniacki is usually consistent around the tour, and not the type to raise her game only for the slams.
Never bet against a Williams sister, particularly one who's won three US Open titles.
Serena's missed nearly an entire year of competition, and has been given a special ranking to enter the tournament. She'll make the most of that second chance.
Like I said, never bet against a Williams sister. Venus has won the US Open twice, although her most recent win was 10 years ago. Now ranked at No. 35 in the world, she's a good outside chance.
She was the runner-up last year, and the finalist at Wimbledon six weeks ago. Vera Zvonareva could easily go one better this time round and take the trophy.
Those are my top seven, assuming Aussie Kim doesn't make it. Who are you tipping to win the US Open this year? Let me know in the comments below.