Williams seeks her 18th Grand Slam and third consecutive U.S. Open title. Djokovic hopes to win his second Slam this year and another U.S. Open.
The oddsmakers ignored rankings and seeding. David Ferrer is ranked No. 5 and seeded No. 4. However, Ferrer is a long-shot at 66-1 odds. Meanwhile, 2012 Champion, Andy Murray, ranked No. 9 and seeded No. 8, is at 4-1 odds.
Victoria Azarenka, runner-up in the past two U.S. Open finals, has seen her ranking slip to No. 17. Yet she is considered a better bet, at 20-1, than Angelique Kerber, seeded No. 6, at 40-1.
That's because when it comes to winning Slams, those with one have a better chance at winning another. Here's a look at how the oddsmakers and Bleacher Report view the chances of the top-five seeds on the men's and women's side.