Day 4 Men's Scores
(1) Rafael Nadal def. Juan Monaco; 6-1, 6-0
(6) Tomas Berdych def. Kevin Anderson; 6-1, 6-4
(7) Andy Murray def. Nicolas Almagro; 6-1, 1-6, 6-4
(9) John Isner def. Marinko Matosevic; 7-6 (9), 6-7 (5), 7-5
Santiago Giraldo def. (11) Jo-Wilfried Tsonga; 6-4, 6-3
(12) Grigor Dimitrov def. Marius Copil; 4-6, 6-3, 7-6 (7)
Feliciano Lopez def. (15) Mikhail Youzhny; 3-6, 6-3, 6-4
Lukasz Kubot def. Gilles Simon; 7-5, 2-6, 6-4
Ernests Gulbis def. Alexandr Dolgopolov; 6-3, 6-4
Marin Cilic def Paul-Henri Mathieu; 6-4, 1-6, 6-2
Jarkko Nieminen def. Igor Sijsling; 6-3, 6-2
Day 4 Women's Scores
(1) Serena Williams def. Shuai Peng; 6-2, 6-3
(3) Agnieszka Radwanska def. Svetlana Kuznetsova; 6-3, 4-6, 7-6 (6)
(4) Simona Halep def. Lara Arruabarrena; 6-4, 6-4
Anastasia Pavlyuchenkova def. (6) Jelena Jankovic; 6-2, 5-7, 7-6 (3)
Roberta Vinci def. (13) Caroline Wozniacki; 6-3, 6-3
(14) Carla Suarez Navarro def. Alison Riske; 6-2, 6-4
(15) Sabine Lisicki def. Irina-Camelia Begu; 6-3, 6-4
Caroline Garcia def. Maria Kirilenko; Walkover
Day 4 Recap
A strong mix of dominant favorites moving on, hotly contested matches and a number of upsets characterized Wednesday's action at the Madrid Open.
Men's No. 1 seed Rafael Nadal dropped just one game in cruising past Juan Monaco, while the top women's seed in Serena Williams had little trouble advancing in a 6-2, 6-3 romp over Shuai Peng.
Nadal discussed his dominant display afterwards.
"Each victory helps to raise your confidence," said Nadal, per the Associated Press, via ESPN.com. "I started a little nervously in my movement. I think I moved better and played well, better than I normally play on the clay. I was dominating over the points and playing very well...I think I've done positive things."
Tomas Berdych also advanced in straight sets, but the next two highest seeds in action for the men had some difficulty. No. 7 Andy Murray has struggled to find his form all season, and that didn't change in his match with Nicolas Almagro. After winning the first set 6-1, he lost the next frame by the same score, then ground out a victory at 6-4 in the decisive set.
Towering American John Isner has always struggled somewhat with consistency, so it wasn't a shock that Marinko Matosevic gave him a serious run. Isner beat Matosevic 11-9 in a first-set tiebreaker, then fell on extra points in the second set before winning the last set 7-5. The 23 aces Isner smashed in the match were the difference.
It took third-seeded Agnieszka Radwanska three sets to move on over Svetlana Kuznetsova, including an 8-6 win in a third-set tiebreak.
Most notable among the upsets was Jelena Jankovic falling to Anastasia Pavlyuchenkova in three sets. Janovic rallied after losing the opening set, but fell short in the final set. Former world No. 1 Caroline Wozniacki also got knocked out in Round 2, putting up little resistance in a 6-3, 6-3 loss to Roberta Vinci.
A premier talent on the men's side in Jo-Wilfried Tsonga was seeded 11th and lost to Santiago Giraldo in straight sets. The three-time Grand Slam semifinalist couldn't capitalize on Giraldo's 52 percent serving success int he second set, losing eight of 10 points on the Colombian's second serve.
Looking ahead to Day 5, there are some compelling showdowns on tap. Perhaps most interesting to watch will be how Isner bounces back from his tough second-round test in facing David Ferrer. Isner is not the most mobile player, and has lost four of five previous matches to Ferrer, whose fitness gives opponents fits, and he will be supported well as a native favorite.
The best match on the women's side has to be talented American Sloane Stephens, who's seeded 16th but has more potential than that ranking suggests. Stephens can prove it Thursday by beating reigning Australian Open champion and No. 2 seed Li Na, who also won the French Open on clay in 2011.