Ireland will be looking for the same sort of Six Nations opening day performance that saw them win in Cardiff last year.
What they will not want to replicate is the miserable remainder of the tournament that followed. It included a defeat to Scotland at Murrayfield Stadium, which they will be looking to avenge on Sunday.
Joe Schmidt has rewarded a number of Ulstermen for their form so far this season, while Scotland coach Scott Johnson has to hope his back line can find some bite in Dublin.
Here are the key head-to-head battles.