After trailing by one point at halftime, the Nuggets torched the Lakers to the tune of 77 second-half points, including 44 in the fourth quarter. Denver shot 19-of-27 in the game's final period and scored 33 points or more in each of the final three quarters.
Nate Robinson led the Nuggets with 21 points, five rebounds and three steals off the bench while fellow point guard Ty Lawson double-doubled with 20 points and 12 assists.
In total, seven Nuggets players finished in double-figures, including Timofey Mozgov (20 points in 21 minutes), Wilson Chandler and Kenneth Faried (17 points apiece).
The 135 points were the most the Nuggets scored this season and the most the Lakers have surrendered over a 48-minute stretch during the 2013-14 campaign.
Denver also outscored the Lakers, 30-9, on the fast break.
Pau Gasol led the Lakers with a complete line of 25 points, 10 rebounds, five assists and three blocks, but was really the team's only bright spot.
Jodie Meeks added 23 points while Nick Young scored 21 off the bench.
Kendall Marshall posted a new career-high with 17 assists, but scored just nine points on 3-of-10 shooting in the blowout loss.
The Lakers will look to rebound on Tuesday against the Dallas Mavericks.