Indianapolis has beaten Tennessee in eight of their last nine meetings and covered the spread three times in a row.
Point Spread: The Titans opened as two-point underdogs. The total was 41.5.
Odds Shark Computer: 23.8-21.2 Colts
Why the Colts Can Cover the Spread
Indy got shocked by St. Louis last week, but it's still 17-8 SU and 16-9 ATS with Andrew Luck at quarterback. The Colts also have yet to lose back-to-back games in a season-and-a-half with Luck.
In fact, Indy is 7-0 both SU and ATS following a loss during the Luck era.
The Titans struggle in divisional action (2-9 ATS) while Odds Shark notes that the Colts are riding a 14-3 SU streak as favorites.
Why the Titans Can Cover the Spread
Tennessee is again without quarterback Jake Locker. According to Paul Kuharsky of ESPN.com, the signal-caller suffered a foot injury on Sunday and is out for the year.
While Tennessee lost twice to the Colts last year, it led both of those games in the fourth quarter.
The Odds Shark computer is predicting an Indy victory and cover and expects this game to play OVER the total. These two teams played two close games last year, with the Colts winning by scores of 19-13 (in overtime) and 27-23.
By the numbers, these two teams are fairly similar.
However, Indy seems to win close games while Tennessee doesn't. Go with the computer on this one.
Colts are 14-3 SU in their past 17 games as road favorites.
Titans are 2-9 ATS in their past 11 divisional games.