This afternoon, we'll see two postseason contenders go head-to-head in a critical Week 10 showdown at Candlestick Park in San Francisco.
Heading into the clash, the 49ers and Carolina Panthers are entrenched in the NFC playoff race as both remain in second place in their respective divisions, so this game could be a difference-maker for the two teams.
Carolina's been one of the league's biggest surprises thus far, as Ron Rivera's boys have reeled off four consecutive victories to get to 5-3, but beating San Francisco on the road would undoubtedly be this team's most impressive victory to date.
For San Francisco, this game is a must-win, especially if Jim Harbaugh's team has any intention of challenging the high-powered Seahawks for NFC West supremacy.
Heading into what should be a very entertaining battle, here are the keys to victory for both teams.
Offense: Get the Passing Game Going Early
As of now, the 49ers boast the game's least effective offense through the air, which is troubling, especially when a quarterback as physically talented as Colin Kaepernick is under center.
With Anquan Boldin, Mario Manningham and Frank Gore all in the mix, Kaepernick has to establish some sort of passing game in order to keep the Panthers' stingy defense honest.
Carolina's defense has been very solid all year, but given that they've been even more impenetrable against the run (currently ranked second in the league), a resurgent effort from Kaepernick's arm would be a big lift.
He's only reached 200 yards passing once in his past five games, and that needs to change against Carolina.
This is a quarterback who has all the tools to carry the mail offensively, even against a solid opposing defense. It's just a matter of remaining consistent from week to week.
Defense: Force Cam Newton to Throw
Cam Newton's been much better during his last four games than he was during the Panthers' first four, but it's not as if the former No. 1 overall pick's faced the most elite opponents during that span.
With the game's No. 25 passing offense, the Panthers have relied on Newton and DeAngelo Williams on the ground to pick up yardage, and San Francisco should be aiming to take advantage of that.
If the 49ers can force Newton to get the job done through the air, Harbaugh's team will certainly have a better chance (at least on paper) of limiting the amount of offensive damage the Panthers do on Sunday.
While the 49ers will certainly get an emotional lift from having Aldon Smith back in the fold, the All-Pro linebacker isn't expected to play a major role against Carolina.
Offense: Establish a Running Game and Get the Receivers Involved
So far, Newton's done a good job of getting the ball to a number of his receiving targets in clutch situations, as Steve Smith, Greg Olsen and Brandon LaFell each have three touchdowns, while Ted Ginn and back Mike Tolbert have two apiece.
In addition, with the three-headed running threat of Newton, Williams and Tolbert, the Panthers have the ability to diversify their attack on the ground, so if the team can accomplish both, Carolina's chances at victory will be much better.
Newton's most effective when the opposing defenses have to be wary of his abilities both with his arm and his legs, so Rivera's offense has to attempt to do both against the 49ers' vaunted defense.
Williams, Tolbert and Newton have a combined nine touchdowns on the ground, so continuing that trend will be very important for this team this afternoon.
As Russell Wilson and Seattle did earlier this season, the Panthers need to get the 49ers on their heels in every way offensively.
Defense: Take Away the Ground Game
Given how little Kaepernick and San Francisco have gotten done through the air, the Panthers and their second-ranked run defense will assuredly be hoping to make the 49ers' passing game carry the mail.
Yes, San Francisco still has three dangerous receiving options, but with Kaepernick sitting at nine touchdowns and five picks thus far, it's clear that the former second-rounder can get rattled when he feels the heat.
In addition to the interceptions, last season's breakout star has fumbled the football five times already this season, so in order for Carolina to emerge victorious, putting pressure on Kaepernick will be critical.
Seattle and Indianapolis have laid a blueprint for the Panthers to follow if they want to limit Kaepernick's impact, and the Panthers might just have the weapons to follow it.