Only four other players, other than those four, have won a slam since Federer won his first in 2003.
As Federer enters the waning stages of his career, now is the best chance for a fresh face to break the run the Big Four have on Grand Slams.
Will it be one of the young guns like Grigor Dimitrov or Milos Raonic? Or perhaps a hungry, slam-less veteran like Jo-Wilfried Tsonga or Tomas Berydch?
Winning a Grand Slam takes skills, persistence, mental toughness and sometimes a little luck.
Sometimes it takes a few failures in finals before the big breakthrough.
Rarely does a player burst onto the scene like then-unseeded 17-year-old Boris Becker and grab a Slam. If it happens again, fans will be stunned and delighted. However, most likely, the players who have the best chance of pushing past the Big Four are in the mix right now.