Besides Rafael Nadal, all the biggest stars will be in action for the 2012 U.S. Open, but which ones are destined to crash and burn in tennis's final Grand Slam event?
Here is a look at three players whose luck of the draw, current form and other factors will not translate to positive results at Flushing Meadows:
David Ferrer: As the No. 4 seed, Ferrer wouldn't normally face too much resistance in the first four rounds, but that may not be the case thanks to his draw.
On the faster surface at the U.S. Open, Ferrer may encounter more trouble than expected early on, as he won't be able to rely as much on his grit and fitness to wear opponents down.
Plus, the upstarts he will face early on have styles similar to his, including a third-round matchup with former world No. 1 and U.S. Open champion Lleyton Hewitt likely awaiting.
The upstart compatriot of Ferrer happens to be his second-round opponent, assuming Gimeno-Traver gets past a qualifier in the opening match.
There are definitely landmines that will require Ferrer's full attention early on, and any slip-up will result in an early exit.
Jo-Wilfried Tsonga: Quite simply, Tsonga is too inconsistent to project as a legitimate contender at the U.S. Open.
A recent loss to 47th-ranked Jeremy Chardy was perplexing, and he has not proven himself as a clear top-tier player.
Last year, Tsonga reached the quarterfinals at the U.S. Open for the first time.
The trend in Grand Slam events for this season has been upward: Fourth round in Australia, quarterfinals at Roland Garros and the semis at Wimbledon. If he maintains that ascending path, Tsonga would reach the final at the U.S. Open.
However, he is slated to once again face Chardy in the third round, and Chardy enters the tournament in fine form fresh off a 6-4, victory over Andy Murray in Cincinnati.
John Isner: The big-serving, 6'9" behemoth of a man has the game to suit the hardcourt style and registered a career-best finish last year by reaching the quarterfinals.
Unfortunately, Isner hasn't been able to build on his Grand Slam success in 2012. In the first three events, he was bounced in the third, second, and first round, respectively.
While his draw is relatively easy in the beginning, the top-ranked American player will likely face a formidable challenger in the fourth round in Richard Gasquet.
Ever since his ban from the game was lifted for a positive cocaine test, Gasquet has been fighting to get his career back on track. He is coming off a loss to underrated Canadian Milos Raonic in Cincinnati, but he beat Isner in the Masters semifinal in Toronto.
Even if Isner bests his previous 2012 Grand Slam results, he will not advance to the quarters for the second straight year because of Gasquet.