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Roger Federer has only won the French Open once. In that same French Open, he didn't have to see Nadal on the other side. In 2009, Federer defeated Robin Soderling for his lone victory in Paris. Federer arguably has the most difficult path to the finals.
He can see an old foe in David Nalbandian in the second round. Nalbandian was one of a handful of players to have a winning record against Federer for a large portion of his career. However, Federer has seemed to solve his former junior singles foe.
Federer could see very dangerous player Tomas Berdych on his path to the 17th grand slam victory. The Swiss saw his potential third-round opponent fall today in Roddick. Federer could also see Djokovic in the semifinals if things fall into place.
Federer had a win on the blue clay courts of Madrid. He's playing good tennis as of late, but he will have to solve the duo of Djokovic and Nadal in the semifinals/finals to add on to his Hall of Fame career.