Samuel, a second-round pick in the 2019 NFL draft, put together a solid rookie season. He was second on the team in receptions (57) and receiving yards (802) and found the end zone on six occasions.
The 24-year-old experienced a setback in the offseason, with NFL Network's Ian Rapoport reporting he underwent surgery for a Jones fracture.
Emmanuel Sanders, who made 10 appearances for San Francisco last season, signed with the New Orleans Saints, and the Niners opted to replace him by using the No. 25 overall pick on Arizona State pass-catcher Brandon Aiyuk.
When it comes to the passing game, the 49ers know what to expect from George Kittle and can count on him to deliver. With Samuel out, they'll need Aiyuk to step up and assume a larger role in the offense.