Titans head coach Mike Vrabel confirmed Henry will have surgery Tuesday but would not give a timeline for his return. When asked if Henry could play again this season, Vrabel said, "There is absolutely a chance."
Ian Rapoport of NFL Network followed up after Vrabel's press conference, saying the Titans expect Henry to return this season:
Ian Rapoport @RapSheet
From NFL Now: <a href="https://twitter.com/hashtag/Titans?src=hash&ref_src=twsrc%5Etfw">#Titans</a> RB Derrick Henry will have foot surgery tomorrow morning and be out 6-10 weeks. Six would be quite fast, eight is more likely. Either way, Tennessee expects Henry back this season. <a href="https://t.co/UzoJqNlcFF">pic.twitter.com/UzoJqNlcFF</a>
Henry was limited at times during the 34-31 overtime win over the Indianapolis Colts, but he still totaled 28 carries and was on the field in the final plays before the game-winning field goal.
A significant injury is scary for the Titans considering his value to the offense. He has tallied 937 rushing yards on 219 carries with 10 touchdowns in 2021, almost double anyone else in the league in rushing with Nick Chubb in second place with 584 yards.
The 27-year-old has won the last two NFL rushing titles, totaling an incredible 2,027 rushing yards last season to rank fifth all-time. He finished 78 yards short of Eric Dickerson's single-season record.
Henry has been nearly unstoppable over the past two years with 3,567 rushing yards and 33 rushing touchdowns in 31 appearances. He also has over 500 yards from scrimmage in four playoff games during this stretch, leading the Titans to the AFC Championship Game after the 2019 season.
Even with the emergence of A.J. Brown and the offseason addition of Julio Jones, the Tennessee offense is reliant on Henry as it keeps its Super Bowl aspirations.
The latest injury puts pressure on Jeremy McNichols, Mekhi Sargent and Adrian Peterson, who signed a contract with the Titans on Monday, to take on bigger roles in the rushing attack.