Manchester United are favoured to win their second UEFA Europa League title in three years this season, and the Red Devils will face Club Brugge in the round of 32 following Monday's draw.
Ole Gunnar Solskjaer's men won Europe's second-tier club contest when Jose Mourinho was at the helm in 2017, and they return to the knockout stages hoping to clinch the continental crown under his Norwegian successor.
Domestic rivals Arsenal also topped their Europa League group and were drawn opposite Olympiacos in the next round; the Gunners are targeting another final appearance after they ended as runners-up to Chelsea last term.
Ajax and Inter Milan are among the biggest names dropping into the fray after they finished third in their UEFA Champions League groups. They were drawn opposite Getafe and Ludogorets Razgrad, respectively, in the round of 32, while Bayer Leverkusen will play Portuguese powerhouse Porto.
Red Bull Salzburg failed to pip Liverpool to a Champions League knockout place and also look like a Europa League contender at 12-1—they'll meet Eintracht Frankfurt in the round of 32.
Steven Gerrard's Rangers earned a runners-up place in their group and are 50-1 outsiders to win the tournament, boasting the incumbent top scorer in Alfredo Morelos (six goals). They'll have to beat Braga over two legs if they're to make the last 16, while Scottish rivals Celtic take on Copenhagen.
The Europa League round-of-32 first-leg fixtures will take place on February 20, while the reverse fixtures are scheduled for February 27.
Here's the round-of-32 draw:
Visit the UEFA website to view the schedule in full
Europa League Winner Odds
Manchester United: 6-1
Inter Milan: 8-1
Red Bull Salzburg: 12-1
Wolverhampton Wanderers: 12-1
AS Roma: 16-1
Bayer Leverkusen: 25-1
Eintracht Frankfurt: 40-1
Shakhtar Donetsk: 50-1
Sporting CP: 50-1
AZ Alkmaar: 70-1
Club Brugge: 100-1
Istanbul Basaksehir: 100-1
LASK Linz: 150-1
Ludogorets Razgrad: 200-1
CFR Cluj: 250-1
APOEL Nicosia: 500-1
The Red Devils have won each of their previous meetings with Club Brugge and emerged as 7-1 victors on aggregate when the two teams clashed in the 2015-16 UEFA Champions League play-offs.
The Belgian outfit have moved on to slightly bigger prospects in the years since, however, and recently forced a 2-2 draw out of Real Madrid away from home in this season's Champions League group stage:
Striker Emmanuel Dennis scored a brace in that clash and hopes to hit the target against another continental titan come February, while Hans Vanaken and David Okereke are among Club Brugge's other threats.
Italian giants Inter will fancy their chances of advancing past Bulgarian league champions Ludogorets, and five-time Europa League winners Sevilla will feel similarly confident going up against Romanian club Cluj.
Things aren't so certain for Arsenal after they drew Greek hopefuls Olympiacos, who hold a strong record against the north Londoners and are something of a bogey team for the English outfit:
The Gunners have one win in their last 12 games across all competitions and are led by interim coach Freddie Ljungberg, but they might have a permanent tactician in place by February.
Premier League peers Wolverhampton Wanderers are also faced with a tricky fixture opposite Espanyol, who have been poor domestically this season but did well to top their pool, per The Athletic's Tim Spiers:
Ajax made it to the semi-finals of last season's Champions League but drop into the Europa League after failing to progress out of their group this season.
They take on a Getafe team that recently celebrated its best start to a campaign in La Liga, a clash that ensures one contender for the title will be packing their bags in the next stage.
Both Glasgow giants have tough round-of-32 tasks at hand. Celtic travel to Copenhagen in their first leg of their clash, while Braga pose a difficult obstacle for a Rangers team unacquainted with knockout football:
A meeting between Primeira Liga champions Benfica and Ukrainian juggernaut Shakhtar Donetsk promises to be the "best of the rest," a tantalising fixture between clubs not originating from Europe's top five leagues.