Per the Associated Press, Kyrgios withdrew from the year's second Grand Slam event on Friday for unspecified reasons.
Per Tennis.com, Kyrgios cited an illness as his reason for withdrawing.
Currently ranked No. 36 in the world, Kyrgios defaulted a May 16 match against Casper Ruud following an on-court outburst in which he kicked a water bottle and threw a chair across the court.
The ATP World Tour announced Kyrgios was fined roughly $22,350 for his antics during the match.
Reuters noted the Australian recently said on Instagram Live that the French Open "sucks" compared to Wimbledon, where he was training with Andy Murray.
Kyrgios was scheduled to face Cameron Norrie in the first round at Roland Garros on Sunday.