Gunners manager Unai Emery has got his team in top form after a tough start, and Arsenal find themselves five points off the top of the Premier League table.
Leicester have blown hot and cold at the start of the campaign, winning four and losing four in their opening eight league matches.
Date: Monday, Oct. 22
Time: 8 p.m. (BST), 3 p.m. (ET)
Odds: Arsenal 11-20, Leicester 11-2, draw 333-100
TV: Sky Sports (UK), NBC Sports Live (U.S.)
Odds according to OddsShark.
The Gunners will believe they have a great chance of a top-four finish this year, with Emery's team boasting plenty of quality.
The core of former manager Arsene Wenger's side remains, but the new boss has quickly found a deadly formula Arsenal were missing during the latter years of the Frenchman's tenure.
Leicester, meanwhile, have been a mixed bag this term, but there's promise in their starting XI.
James Maddison has been a breakout star in the Premier League this season and consequently forced his way into the England squad. The 21-year-old joined the Foxes for £20 million in the summer and wasted no time making his mark.
He has three goals and two assists in eight Premier League appearances, and his ability on the ball will cause Arsenal problems.
Alexandre Lacazette and Pierre-Emerick Aubameyang are coming into their own as a partnership, and the pair could soon be considered the most destructive duo in English football.
Both Arsenal players have the quality to breach the best defences, and Foxes centre-back Harry Maguire will be kept busy.
According to Sky Sports, Mesut Ozil is back in training for the hosts after a back issue, with Danny Welbeck also expected to be available for selection after a recent knock. Wes Morgan will be missing through suspension for the away team after his dismissal against Everton. Matty James and Demarai Gray are also expected to be out of the Foxes squad with injury.
The Gunners will feel supremely confident going into Monday night's game, but they must not take the Foxes lightly.
Jamie Vardy remains a predator, and the simplicity of his game will cause Emery a tactical challenge.
The striker will work the Arsenal back four hard as he hunts for opportunities, and Emery's men cannot make a mistake with Maddison pulling the strings as the No. 10.