New manager Maurizio Sarri will take charge of the Blues for the first time in England's top flight. He faces a Terriers side that finished 16th in the table last season.
The campaign was Huddersfield's first in the Premier League. They will be looking to consolidate their position in the division this time around.
Chelsea are favourites to win but will need no reminding they were stunned 3-2 by Burnley on the opening day of last season. The Blues were also comfortably beaten by Manchester City in the 2018 Community Shield on Sunday.
All odds, per OddsShark. Odds accurate at the time of writing.
Date: Saturday, August 11
Time: 3 p.m. BST/10 a.m. ET
TV Info: NBCSN (U.S.)
Live Stream: NBCSports.com (U.S.)
It's been a summer of big change at Stamford Bridge. Manager Antonio Conte has been replaced by Sarri, and the club have spent heavily on midfielder Jorginho and goalkeeper Kepa Arrizabalaga.
The 23-year-old has signed from Athletic Bilbao and cost the Blues £71.6 million, per Michael Hincks at Sky Sports.
It's a world-record fee for a goalkeeper who should go straight into the first team. He will have to adapt quickly to a new country and a new league.
Football writer Graham Ruthven offered his view:
Chelsea's best bit of business may be keeping Eden Hazard at the club. The Belgian is the team's talisman and had emerged as a transfer target for Real Madrid, per Sam Wallace at the Daily Telegraph. However, with Premier League players still able to leave their clubs for La Liga until 11:59 p.m. CET on August 31, he could still depart.
Striker Olivier Giroud explained the importance of keeping hold of Hazard, per Simon Johnson at the Evening Standard:
Sarri has a reputation for creating exciting, attacking teams, and much will be expected of the Blues under their new manager.
He has said his team may not be at full strength for their opening match:
Chelsea's defeat to Manchester City highlighted the strength of Pep Guardiola's side, who are strong favourites to retain their Premier League crown. The Blues can ill-afford a slow start to the season if they are to challenge the Citizens for the title.
Huddersfield were largely written off at the start of last season but surprised many by staying up and achieving some excellent results. The Terriers confirmed their Premier League status with a 1-1 draw against Chelsea at Stamford Bridge in their penultimate match of the campaign.
It looks like being another tough season for the club even though they have added to their squad by bringing in Ramadan Sobhi, Adama Diakhaby and Terence Kongolo on a permanent deal.
Freelance writer Huw Davies expects them to struggle:
Huw Davies @thehuwdavies
@TMortimerFtbl I definitely think they'll be in the bottom four – the question is bottom three. They could well go down. Their defensive stats were pretty good last season, though, and keeping Kongolo is big. You're right that their attacking signings aren't inspiring, but Wagner's very good.
Manager David Wagner has done a brilliant job since taking over. He kept the team in the Championship in his first season before winning promotion in the following campaign.
Keeping the club in the Premier League again looks another difficult challenge. The team's defensive organisation is their strength, but they may struggle to score the goals required to keep them in the top flight.