Tottenham Hotspur will welcome Manchester United to Wembley Stadium on Wednesday in Week 25 of the Premier League.
United sit in second place in the standings, 12 points back on leaders Manchester City. They will be looking over their shoulder come Wednesday, as Tottenham, who are fifth, can cut the gap to the Red Devils to just five points with a victory.
Elsewhere, City face West Bromwich Albion, while Liverpool visit Huddersfield Town seeking to recover from their loss to Swansea City last time out in the league. The Welsh side host Arsenal on Tuesday.
Here are the fixtures in full for this midweek round of games, a prediction for each and a closer look at a couple of the standout matches on the agenda.
Tuesday, January 30
7:45 p.m. Swansea City vs. Arsenal (1-2)
7:45 p.m. West Ham United vs. Crystal Palace (2-2)
8 p.m. Huddersfield Town vs. Liverpool (0-3)
Wednesday, January 31
7:45 p.m. Chelsea vs. Bournemouth (2-0)
7:45 p.m. Everton vs. Leicester City (1-1)
7:45 p.m. Newcastle United vs. Burnley (1-1)
7:45 p.m. Southampton vs. Brighton & Hove Albion (1-0)
8 p.m. Manchester City vs. West Bromwich Albion (3-0)
8 p.m. Stoke City vs. Watford (2-1)
8 p.m. Tottenham Hotspur vs. Manchester United (2-1)
Kick-offs are in GMT.
Huddersfield Town vs. Liverpool
All the positive momentum built up by Jurgen Klopp's Reds was sapped away in south Wales last week, as Liverpool toiled in a 1-0 loss to Swansea.
The defeat ended an impressive unbeaten run of 18 games, and it's imperative they don't make similar mistakes against Huddersfield on Tuesday.
As noted by fan website This Is Anfield on Twitter, the Reds are a difficult side to get a grasp on at the moment:
Klopp's team are in fourth place and just a couple of points ahead of Tottenham, who head to Anfield for a huge game on Sunday. Three points at the John Smith's Stadium would be so important with that fixture in mind.
Huddersfield appear vulnerable, too, as they are clearly feeling the effects of the Premier League season. After a bright start, head coach David Wagner has witnessed his team's form take a downward turn; they are without a win in six and have lost their last three games in a row.
They have been especially shaky in defence, and given the Reds will be desperate to respond after their Swansea shambles, expect the visitors to be too strong here.
Prediction: Huddersfield Town 0-3 Liverpool
Tottenham Hotspur vs. Manchester United
Although Spurs had some teething issues at Wembley, it appears they have started to enjoy playing at the national stadium in recent weeks.
United need to be wary as a result. It's at this point in campaigns under manager Mauricio Pochettino where Spurs tend to click into gear and put together runs that move them up the table. And while they were below their best in the 1-1 draw with Southampton in the league last time out, they have been performing well.
That certainly goes for Harry Kane, who continues to set new standards with his goalscoring. Per OptaJoe, United will have to look out for him:
The Red Devils have a new attacking talisman they can unleash in the shape of Alexis Sanchez, who will no doubt be in for a spiky reception on Wednesday as a former Arsenal player.
The midseason capture of the Chile international is a big coup for United, and he impressed in glimpses on Friday in the FA Cup win at Yeovil Town.
Squawka Football took a look at Sanchez's display against the League Two side statistically:
It's these types of matches, away from home to a big rival, where Red Devils supporters will want to see him make the difference. Nevertheless, Spurs are an excellent side on home soil and have the attacking class to unsettle United; they will do just enough here.
Prediction: Tottenham Hotspur 2-1 Manchester United