United are eight points behind City, who play on Sunday. The Gunners are a further four points back and have Liverpool snapping at their heels in the race for UEFA Champions League football.
Read on for a closer look at the match, but first some viewing details and the latest team news.
Date: Saturday, December 2
Time: 5:30 p.m GMT, 12:30 p.m. ET
TV: BT Sport 1 (UK), NBC (U.S.)
After Alexandre Lacazette was substituted during the Gunners' 5-0 win over Huddersfield Town on Wednesday, manager Arsene Wenger told the press the striker "has a groin problem and will certainly be out for Saturday's game."
Both sides come into the contest on the back of wins, with United having beaten Watford 4-2 at Vicarage Road on Tuesday.
It looked as though it would be far more comfortable for the Red Devils after their ruthless showing in the early stages of the match. Football writer Liam Canning was impressed:
Despite a sloppy period late on, during which the team conceded twice before killing off the match, United were largely excellent.
Ashley Young grabbed the headlines with a superb brace, but another player to impress was Anthony Martial, who also got on the scoresheet.
ESPN FC's Rob Dawson praised the forward:
The Frenchman provided an electric presence in the final third, and he will be one of the biggest threats to Arsenal on Saturday. If he's at his best at the Emirates Stadium, Martial will be difficult to deal with.
The same goes for Mesut Ozil going the other way if he can replicate his performance against Huddersfield. The German decided that game by contributing two assists and a goal in the space of just four minutes.
As ESPN FC's Mattias Karen noted, Ozil was able to coax a goal from Alexis Sanchez despite the Chilean being below his best:
The key will be whether he can have a similar impact against much stronger opposition, and with Arsenal at home, the chances of that happening are more likely.
The Gunners are a force to be reckoned with on their own turf, as the Premier League demonstrated:
United have a good chance of breaking that streak by getting something out of the game, but it promises to be an intriguing encounter that should hold plenty of entertainment, particularly if the likes of Martial and Ozil can light it up once again.