EPL Predictions: Picks, Top Players for Week 4 Premier League Fixtures

Jose Mourinho's Manchester United will meet Pep Guardiola's Manchester City for the first time on Saturday, with both sides looking for an early advantage in the Premier League title race.

Away from Old Trafford, Arsenal will host Southampton as the Gunners seek to continue clawing their way up the table following their poor start, while champions Leicester City will travel to Liverpool.

Tottenham Hotspur will make the trip to Stoke City, Chelsea will do the same at Swansea City and Hull City's surprising start could continue if they can pick up a win at Burnley.

Here is the complete schedule for Week 4, complete with predictions and a look at who to keep an eye on over the weekend:

Date	Time (BST/ET)	Fixture	Prediction
Saturday, September 10	12:30 p.m./7:30 a.m.	Manchester United vs. Manchester City	2-1
Saturday, September 10	3 p.m./10 a.m.	Arsenal vs. Southampton	3-0
Saturday, September 10	3 p.m./10 a.m.	Bournemouth vs. West Bromwich Albion	1-1
Saturday, September 10	3 p.m./10 a.m.	Burnley vs. Hull City	2-2
Saturday, September 10	3 p.m./10 a.m.	Middlesbrough vs. Crystal Palace	2-0
Saturday, September 10	3 p.m./10 a.m.	Stoke City vs. Tottenham Hotspur	1-2
Saturday, September 10	3 p.m./10 a.m.	West Ham United vs. Watford	1-0
Saturday, September 10	5:30 p.m./12:30 p.m.	Liverpool vs. Leicester City	2-2
Sunday, September 11	4 p.m./11 a.m.	Swansea City vs. Chelsea	0-3
Monday, September 12	8 p.m./3 p.m.	Sunderland vs. Everton	1-2

Paul Pogba, Manchester United

After facing Southampton and Hull in his first two games back with the Red Devils, Paul Pogba will face his first huge test at Old Trafford on Saturday in the Manchester derby.

Mark Runnacles/Getty Images

The Frenchman enjoyed an outstanding debut against the Saints, as football writer Liam Canning noted:

Pogba—and the rest of the United side—were somewhat less impressive in the following game with Hull amid a resolute display by the Tigers, but he again showed his qualities on international duty with France, per sports journalist Jonas Giaever:

After the Red Devils spent £89 million to bring him back to Old Trafford, the derby is the kind of game Pogba will be expected to stamp his authority on—to dictate the tempo and control the midfield in United's favour.

Against the creative powers of Kevin De Bruyne and David Silva—as well as the industrious Fernandinho—that will be no easy task, but alongside the resurgent Marouane Fellaini, he may be able to do it.

Further, he's more than capable of supplying a match-winning goal or assists—it would not be a surprise if he makes the difference on Saturday.

Daniel Amartey, Leicester City

The Foxes did a phenomenal job in keeping their title-winning stars at the King Power Stadium over the summer, with the sole exception of N'Golo Kante.

Kante was an incredibly crucial figure in midfield, so replacing him is the key for Leicester to enjoy another strong campaign.

Rui Vieira/Associated Press

In January signing Daniel Amartey, they may have found it. The 21-year-old, who can also play in defence, is hardworking and a natural ball-winner.

He put in an excellent performance last time out as Leicester beat Swansea, per BBC Sport's Tom Brown and FourFourTwo's Joe Brewin:

According to the Press Association (h/t the Daily Mail), Leicester boss Claudio Ranieri would not entertain comparisons with Kante but nevertheless hailed his contribution:

"

I don't want to speak of Kante. There is only one—there isn't another in the world. He has gone and now we need to move on.

But Amartey played very, very well. He now knows very well the Premier League. He can play centre back, central midfielder, right-back, right winger and I am very pleased with him. He played very well, was solid, strong and recovered a lot of balls.

"

If Amartey can put in the kind of shift he did against the Swans, the Foxes have a good chance of coming away from Anfield with a positive result.

Without a resolute showing in defence and midfield, the Reds' firepower could prove too much.

Moussa Sissoko, Tottenham Hotspur

Moussa Sissoko's deadline-day transfer to Spurs raised more than a few eyebrows given the fee involved.

Indeed, Bleacher Report UK's own Dean Jones ranked it as one of the worst signings of the summer:

The Frenchman is capable of producing exceptional performances—he's quick, powerful, a good dribbler and a creative presence in the final third—and he showed as much during UEFA Euro 2016.

However, Sissoko has spent much of the last two years with Newcastle United and shown little fight or desire to produce his best form, which played a significant part in the Magpies' relegation.

The Northern Echo's Scott Wilson noted as much on deadline day as Everton tried and failed to sign him:

Sissoko arrives at White Hart Lane with a point to prove, and he'll be eager to impress at his new club.

A big question mark remains over his attitude and whether he'll continue to perform for the Lilywhites in the long term—particularly if the club faces a difficult spell—but in the short term, he should be producing strong showings, and Spurs can reap the rewards against Stoke.