Barcelona allayed any fears of final-day tension at the top of La Liga as they secured the title with a 1-0 victory over Atletico Madrid on Sunday.
Real Madrid are forced to settle for second place, while Atleti are assured of a top-four finish. Valencia and Sevilla are the final two teams vying for a Champions League spot.
At the bottom, Cordoba were confirmed for the drop earlier this month, but any two of Almeria, Eibar, Granada and Deportivo La Coruna could still go down.
Read on for a look at all of the permutations from the last day of fixtures and the latest standings ahead of Saturday's action.
|La Liga Standings|
|17||Deportivo La Coruna||37||7||13||17||33||58||-25||34|
|La Liga Fixtures: Week 38|
|May 23||3:30 p.m./10:30 a.m.||Levante vs. Elche|
|May 23||5:30 p.m./12:30 p.m.||Almeria vs. Valencia|
|May 23||5:30 p.m./12:30 p.m.||Athletic Bilbao vs. Villarreal|
|May 23||5:30 p.m./12:30 p.m.||Barcelona vs. Deportivo La Coruna|
|May 23||5:30 p.m./12:30 p.m.||Celta Vigo vs. Espanyol|
|May 23||5:30 p.m./12:30 p.m.||Eibar vs. Cordoba|
|May 23||5:30 p.m./12:30 p.m.||Granada vs. Atletico Madrid|
|May 23||5:30 p.m./12:30 p.m.||Malaga vs. Sevilla|
|May 23||5:30 p.m./12:30 p.m.||Rayo Vallecano vs. Real Sociedad|
|May 23||7:30 p.m./2:30 p.m.||Real Madrid vs. Getafe|
Though the top two spots have already been confirmed, the third and the fourth places are still to be decided.
Atletico will be eager to secure third place as it would see them qualify directly into the Champions League group stages.
However, Valencia could leapfrog the 2013-14 La Liga champions by virtue of their head-to-head record if Atleti lose away to Granada and Los Che win at Almeria.
However, a point for Diego Simeone's men would secure third spot.
Looking behind them, Valencia could also drop to fifth if Sevilla beat Malaga away and Nuno's side fail to win.
If Sevilla fail to nick fourth, they could still be in the Champions League next season, as they will qualify if they beat Dnipro in the Europa League final on May 27.
It is very tight at the bottom of La Liga, with Almeria and Eibar currently on 32 points in 18th and 19th and Depor and Granada two points ahead on 34.
Almeria and Eibar both have to win to have a chance of avoiding the drop, with the former facing a huge challenge at home to Valencia and the latter facing already relegated Cordoba.
However, Cordoba do have an incentive to take Eibar down with them, per Spanish football writer Chris Moar:
Depor face an incredibly tough challenge away to Barca, although manager Luis Enrique may well be inclined to rest a few players with a Copa del Rey and a Champions League final still to come.
Granada face similar difficulty at home to Atleti. There is a scenario in which all four teams could end up on 35 points—if Almeria and Eibar both win, while Granada and Depor draw.
It would then go down to head-to-head record. The permutations are almost endless. In fact, there are 81 of them, per AS:
The two sides currently holding the relegation spots are the favourites to go down, but given the difficulty of the other teams' fixtures, Eibar may just hold an edge with only Cordoba to turn over.
Villarreal have confirmed sixth spot and will be joined in the Europa League by the team who finishes fifth—either Valencia or Sevilla.
However, there could be a third team in the Europa League from Spain next season, and it is likely to be Athletic Bilbao.
Athletic can gain their spot with a win over Barca in the Copa del Rey final or, failing that, a seventh-placed finish in the league.
Athletic are currently in seventh, but they can be overtaken by Malaga if they fail to beat Villarreal at home and Los Boquerones beat Sevilla.
If that happens, and Athletic lose in the Copa del Rey final, Malaga will move on to the Europa League.