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CLEVELAND, OH - OCTOBER 15: San Francisco 49ers quarterback Brock Purdy (13) walks to the sideline during the fourth quarter of the National Football League game between the San Francisco 49ers and Cleveland Browns on October 15, 2023, at Cleveland Browns Stadium in Cleveland, OH. (Photo by Frank Jansky/Icon Sportswire via Getty Images)
CLEVELAND, OH - OCTOBER 15: San Francisco 49ers quarterback Brock Purdy (13) walks to the sideline during the fourth quarter of the National Football League game between the San Francisco 49ers and Cleveland Browns on October 15, 2023, at Cleveland Browns Stadium in Cleveland, OH. (Photo by Frank Jansky/Icon Sportswire via Getty Images)Frank Jansky/Icon Sportswire via Getty Images

49ers vs. Vikings: Updated Odds, Money Line, Spread, Props to Watch for MNF

Michelle BrutonOct 23, 2023

Coming off their first loss of the season in Week 6, the San Francisco 49ers look to right the ship against the Minnesota Vikings on Monday Night Football.

Though this may have looked like a high-scoring barnburner when it was initially scheduled, injuries have taken their toll on both squads through six weeks and key offensive players are missing on both sides.

The 49ers will be without top wideout Deebo Samuel and the league's most productive running back in Christian McCaffrey. The Vikings are staring down another week without top wideout Justin Jefferson, who was placed on injured reserve ahead of Week 6.

With uncertainty surrounding both squads, this week's props require some parsing. But there are three intriguing ones you should take a closer look at. Let's break them down, along with the spread and money line for Monday night's game.

Schedule, Odds and Spread

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MINNEAPOLIS, MINNESOTA - OCTOBER 08: T.J. Hockenson #87 of the Minnesota Vikings looks on against the Kansas City Chiefs in the second half at U.S. Bank Stadium on October 08, 2023 in Minneapolis, Minnesota. The Chiefs defeated the Vikings 27-20. (Photo by David Berding/Getty Images)
MINNEAPOLIS, MINNESOTA - OCTOBER 08: T.J. Hockenson #87 of the Minnesota Vikings looks on against the Kansas City Chiefs in the second half at U.S. Bank Stadium on October 08, 2023 in Minneapolis, Minnesota. The Chiefs defeated the Vikings 27-20. (Photo by David Berding/Getty Images)

Monday Night Football: San Francisco 49ers vs. Minnesota Vikings

Date: Monday, Oct. 23

Location: U.S. Bank Stadium, Minneapolis, Minnesota

Time: 8:15 p.m. ET

TV: ESPN, ABC

Live Stream: ESPN app, ABC app


Updated Monday Night Football Odds

Spread: 49ers -6.5 (-115), Vikings +6.5 (-105)

Money Line: 49ers -305 (bet $305 to win $100), Vikings +245 (bet $100 to win $245)

Total 43 (Over: -108; Under: -112)

Odds current as of 11:30 p.m. ET Sunday, Oct. 22

MNF Props to Watch

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CHICAGO, ILLINOIS - OCTOBER 15: Kirk Cousins #8 of the Minnesota Vikings warms up before the game against the Chicago Bears at Soldier Field on October 15, 2023 in Chicago, Illinois. (Photo by Michael Reaves/Getty Images)
CHICAGO, ILLINOIS - OCTOBER 15: Kirk Cousins #8 of the Minnesota Vikings warms up before the game against the Chicago Bears at Soldier Field on October 15, 2023 in Chicago, Illinois. (Photo by Michael Reaves/Getty Images)

T.J. Hockenson Anytime TD (+225)

The unicorns in prop bets are high-value propositions that still exist firmly within the realm of reality, and that's exactly the case for Vikings tight end T.J. Hockenson and his chances of finding the end zone on Monday night.

As the Vikings prepare to take on the 49ers on Monday night, they do so without wide receiver Justin Jefferson, who was placed on injured reserve ahead of Week 6 with a hamstring injury.

Before he got injured, Jefferson had racked up more than 100 yards in three games and had found the end zone three times. That production had to be made up somewhere, and while Hockenson is unlikely to put up Justin Jefferson numbers (especially against the 49ers secondary), he will be one of Kirk Cousins' go-to looks in the red zone. Hockenson ranks fifth in red-zone targets among tight ends this season, per FantasyPros.


Kirk Cousins Over 0.5 INTs (-130)

With four picks on the season so far, Kirk Cousins isn't among the NFL's worst offenders. The quarterback with the most interceptions, the Las Vegas Raiders' Jimmy Garoppolo, has twice that.

But on Monday, Cousins will face a ruthless 49ers defense that leads the league in interceptions this season, with 10. And given how high-scoring the 49ers offense is, averaging 30.7 points per game, Cousins and the Vikings are going to be forced to take to the air to keep pace.

That's exactly what San Francisco's secondary hopes to see.


Brock Purdy Under 235.5 Passing Yards (-115)

This isn't a sneaky high-value prop, but it also isn't an overly risky one.

Though there's a world in which the Vikings secondary, which has allowed opposing quarterbacks the 13th-highest yards per attempt this season, gives Purdy the room he needs to air it out, betting low on Purdy in Week 7 is the move.

Purdy has amassed less than 235 passing yards three times this season. He's coming off his worst game of the year so far, having totaled just 125 yards against the Cleveland Browns in the 49ers' first loss.

With wideout Deebo Samuel ruled out with a shoulder injury, expect Purdy to have another low-volume game on Monday.


Monday Night Football odds from DraftKings.

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