College Football Week 13 Picks: Picking All 54 Games Against the Spread

As we come down to the final few weeks of the college football regular season, there are several programs that are thankful for their impressive play throughout the 2010 season.

In Tuscaloosa, Cam Newton and Auburn will look to knock off in-state rival and defending national champion Alabama, as the Tigers are in the driver’s seat for a shot at the national championship in January along with the Oregon Ducks.

Speaking of the Ducks, they will bring their high-powered offense once again as they welcome Arizona to the Zoo this Saturday, as only the Civil War with Oregon State remains on the schedule.

For the BCS busters, No. 3 TCU will have to look impressive against New Mexico this weekend, as the Lobos might hurt the chances of the team of getting into the national championship game if one of the top two were to fall this season.

On their heels, Boise State could potentially jump the aforementioned Horned Frogs this week, as the Broncos travel to play a ranked Nevada squad that could pad the résumé for their opportunity to play for the title in Glendale.

With all that being said, let’s get to the picks for this week’s slate of games this weekend...

This article is also featured on A Blue and Gold State of Mind.

Atlantic Coast Conference

Mike Ehrmann/Getty Images

MIAMI - NOVEMBER 20: Tyrod Taylor #5 of the Virginia Tech Hokies celebrates with teammate Jarrett Boykin #81 after rushing for a touchdown during a game against the Miami Hurricanes at Sun Life Stadium on November 20, 2010 in Miami, Florida. (Photo by M

Saturday, November 27th

Boston College at Syracuse (-3)

Pick: Syracuse

Virginia at Virginia Tech (-23.5)

Pick: Virginia Tech

South Florida at Miami (-11.5)

Pick: South Florida

North Carolina State (-2.5) at Maryland

Pick: NC State

Florida at Florida State (-2.5)

Pick: Florida State

North Carolina (-9.5) at Duke

Pick: North Carolina

South Carolina (-3) at Clemson

Pick South Carolina

Wake Forest at Vanderbilt (-6)

Pick: Vanderbilt

Big East Conference

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LOUISVILLE, KY - NOVEMBER 20: Noel Devine #7 of the West Virginia Mountaineers runs with the ball during the Big East Conference game against the Louisville Cardinals at Papa John's Cardinal Stadium on November 20, 2010 in Louisville, Kentucky. (Photo b

Friday, November 26th

Louisville at Rutgers

Pick: Louisville (-3)

West Virginia at Pittsburgh

Pick: West Virginia (-2.5)

Saturday, November 27th

Boston College at Syracuse (-3)

Pick: Syracuse

Cincinnati at Connecticut (-1.5)

Pick: UConn

Big Ten Conference

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ANN ARBOR, MI - NOVEMBER 20: Scott Tolzien #16 of the Wisconsin Badgers throws a second quarter pass to Lance Kendricks #84 in front of Courtney Avery #5 of the Michigan Wolverines at Michigan Stadium on November 20, 2010 in Ann Arbor, Michigan. (Photo

Saturday, November 27th

Indiana at Purdue (-3)

Pick: Indiana

Michigan State (-2) at Penn State

Pick: Penn State

Michigan at Ohio State (-17)

Pick: Ohio State

Northwestern at Wisconsin (-23)

Pick: Wisconsin

Iowa (-15.5) at Minnesota

Pick: Iowa

Big 12 Conference

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STILLWATER, OK - SEPTEMBER 05: Wide receiver Justin Blackmon #81 of the Oklahoma State Cowboys warms up before the college football game against the Georgia Bulldogs at Boone Pickens Stadium on September 5, 2009 in Stillwater, Oklahoma. The Cowboys defe

Thursday, November 24th

Texas A&M (-3.5) at Texas

Pick: Texas A&M

Friday, November 25th

Colorado at Nebraska

Pick: Nebraska

Saturday, November 27th

Missouri (-24.5) at Kansas

Pick: Missouri

Kansas State (-14.5) at North Texas

Pick: Kansas State

Houston at Texas Tech (-9.5)

Pick: Texas Tech

Oklahoma at Oklahoma State (-3)

Pick: Oklahoma State

Conference USA

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BLACKSBURG, VA - SEPTEMBER 18: Running back Giavanni Ruffin #1 of the East Carolina Pirates runs with the ball for a touchdown past defensive tackle Dwight Tucker #53 of the Virginia Tech Hokies at Lane Stadium on September 18, 2010 in Blacksburg, Virgin

Friday, November 26th

SMU at East Carolina (-1)

Pick: East Carolina

Southern Miss at Tulsa (-3.5)

Pick: Southern Miss

Saturday, November 27th

UCF (-25.5) at Memphis

Pick UCF

Tulane at Marshall (-9)

Pick: Marshall

UAB (-3) at Rice

Pick: Rice

Houston at Texas Tech (-9.5)

Pick: Texas Tech

Mid-American Conference

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BLOOMINGTON, IN - NOVEMBER 01: Quarterback Brian Brunner #18 of the Central Michigan Chippewas passes the ball during the game against the Indiana Hooisers at Memorial Stadium on November 1, 2008 in Bloomington, Indiana. (Photo by Andy Lyons/Getty Image

Friday, November 26th

Ohio at Kent State (-3)

Pick: Kent State

Northern Illinois (-23.5) at Eastern Michigan

Pick: Northern Illinois

Western Michigan (-6.5) at Bowling Green

Pick: Western Michigan

Central Michigan at Toledo (-3.5)

Pick: Toledo

Buffalo at Akron (PK)

Pick: Buffalo

Mountain West Conference

George Frey/Getty Images

SALT LAKE CITY, UT - NOVEMBER 6: Quarterback Andy Dalton #14 of the TCU Horned Frogs throws a pass against the Utah Utes during the second half of an NCAA Football game November 6, 2010 at Rice-Eccles Stadium in Salt Lake City, Utah. TCU Beat Utah 47-7.

Saturday, November 27th

BYU at Utah (-9)

Pick: Utah

TCU (-43) at New Mexico

Pick: TCU

UNLV at San Diego State (-24)

Pick: San Diego State

Pac-10 Conference

Ezra Shaw/Getty Images

BERKELEY, CA - NOVEMBER 13: LaMichael James #21 of the Oregon Ducks in action during their game against the California Golden Bears at California Memorial Stadium on November 13, 2010 in Berkeley, California. (Photo by Ezra Shaw/Getty Images)

Friday, November 26th

UCLA at Arizona State (-13)

Pick: UCLA

Arizona at Oregon (-19.5)

Pick: Oregon

Saturday, November 27th

Washington at California (-7)

Pick: Washington

Oregon State at Stanford (-14)

Pick: Stanford

Notre Dame at USC (-4)

Pick: USC

Southeastern Conference

Kevin C. Cox/Getty Images

AUBURN, AL - NOVEMBER 13: Quarterback Cameron Newton #2 of the Auburn Tigers rushes for a touchdown past Bacarri Rambo #18 of the Georgia Bulldogs at Jordan-Hare Stadium on November 13, 2010 in Auburn, Alabama. (Photo by Kevin C. Cox/Getty Images)

Friday, November 26th

Auburn at Alabama (-4.5)

Pick: Alabama

Saturday, November 27th

Kentucky at Tennessee (-3)

Pick: Tennessee

Florida at Florida State (-2.5)

Pick: Florida State

LSU at Arkansas (-3.5)

Pick: LSU

South Carolina (-3) at Clemson

Pick South Carolina

Mississippi State (-3) at Mississippi

Pick: Mississippi State

Wake Forest at Vanderbilt (-6)

Pick: Vanderbilt

Georgia Tech at Georgia (-12.5)

Pick: Georgia

Sun Belt Conference

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GAINESVILLE, FL - SEPTEMBER 12: Brandon James #25 of the Florida Gators breaks the tackle of John Birmingham #22 of the Troy Trojans during the game at Ben Hill Griffin Stadium on September 12, 2009 in Gainesville, Florida. (Photo by Sam Greenwood/Getty

Saturday, November 27th

Western Kentucky at Troy (-13)

Pick: Troy

Florida Atlantic at Middle Tennessee (-4.5)

Pick: Florida Atlantic

Louisiana-Lafayette at Louisiana-Monroe (-7)

Pick: Louisiana Monroe

Western Athletic Conference

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BOISE, ID - NOVEMBER 19: Kellen Moore #11 of the Boise State Broncos passes against the Fresno State Bulldogs at Bronco Stadium on November 19, 2010 in Boise, Idaho. (Photo by Otto Kitsinger III/Getty Images)

Friday, November 26th

Boise State (-14) at Nevada

Pick: Boise State

Saturday, November 27th

Hawaii (-26.5) at New Mexico State

Pick: Hawaii

Louisiana Tech (-11.5) at San Jose State

Pick: Louisiana Tech

Idaho at Fresno State (-11)

Pick: Fresno State