Per ESPN's Adam Schefter, Swift has been ruled out with a concussion.
Lions running backs coach Kyle Caskey told reporters that Adrian Peterson will be their leadoff running back, with Kerryon Johnson playing Swift's role.
Coming into Week 11, Peterson has a slight edge in touches over Swift (108-101), with Johnson at 38.
Peterson and Johnson have been roughly identical as runners, though Peterson has a much larger sample size to judge. He's averaging 3.8 yards per carry on 97 attempts; Johnson averages 3.7 yards per attempt on 30 carries.
The 35-year-old Peterson has never done much in the passing game throughout his NFL career, and he has just 11 catches for 78 yards. Swift's versatility as a receiver is why his absence will be noteworthy. His 31 catches are only five off T.J. Hockenson's team-leading 36.
Johnson also is a bit limited as a pass-catcher as well but did haul in 32 grabs as a rookie in 2018. If he's going to be used in the Swift role, that gives him the upside of a flex play against a Panthers defense that's allowed the 10th-most points to running backs through 10 weeks.