Kansas City's top two running backs split playing time in road victories over the Baltimore Ravens and Oakland Raiders.
McCoy has been far more effective with 104 yards on 21 attempts (5.0 YPC). He's added four receptions for 12 yards.
Williams tallied just 34 yards on 22 attempts (1.5 YPC) but recorded the team's only rushing touchdown, and he caught nine passes for 87 yards.
McCoy, who signed with the Chiefs after being released by the Buffalo Bills during final roster cuts ahead of the regular season, could see upward of 20 touches if active Sunday.
"It was nice just watching it how fast they were going up and down the field, how much space they had, how many opportunities they had and the gains they were getting each play," he told reporters after Week 1. "At one point in the game we were averaging 15 yards per touch. That's not normal. To see it firsthand is pretty cool."
Darwin Thompson, K.C.'s sixth-round pick in the 2019 NFL draft, should also see a far more expansive role with Williams sidelined. He had only one carry and one catch through the first two games.
The Chiefs' rushing attack figures to face serious resistance from a Ravens defense that's allowing just 20.5 rushing yards against per game so far this season, the best mark in the league.
So the burden will once again fall on quarterback Patrick Mahomes and the passing attack to carry the Kansas City offense against counterpart Lamar Jackson and Baltimore in a battle of undefeated teams.