NFL.com's Daniel Jeremiah reported Thursday that "many around the league" expect the Colts to trade down again in an effort to accumulate more picks and reshape the roster.
Indy previously dealt the No. 3 overall selection to the New York Jets for the No. 6 overall pick and three second-round selections (two in 2018 and one in 2019).
USC's Sam Darnold, UCLA's Josh Rosen, Oklahoma's Baker Mayfield and Wyoming's Josh Allen are all considered likely high picks in the first round at quarterback.
Since the Colts have an all-world quarterback in Andrew Luck if he is healthy, they are dealing from a position of strength.
Buffalo owns both the No. 12 and No. 22 overall selections, and it is a prime candidate for a trade up since the top two quarterbacks on its depth chart currently are AJ McCarron and Nathan Peterman.
The Bills' interest in a trade will likely depend on how the quarterback situation plays out among other quarterback-needy teams picking higher in the first round, including the Cleveland Browns, New York Giants, New York Jets and Denver Broncos.
Since the Cards have only one first-round pick, they may be at the mercy of Buffalo and what it decides to do.
With regard to the Colts, Bleacher Report's Matt Miller projected in his latest mock draft that they will trade down from No. 6 to No. 12 with the Bills, resulting in Buffalo selecting Rosen.