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Manchester City's Spanish manager Pep Guardiola (L) and Tottenham Hotspur's Argentinian head coach Mauricio Pochettino gesture on the touchline during the English Premier League football match between Tottenham Hotspur and Manchester City at White Hart Lane in London, on October 2, 2016. / AFP / Glyn KIRK / RESTRICTED TO EDITORIAL USE. No use with unauthorized audio, video, data, fixture lists, club/league logos or 'live' services. Online in-match use limited to 75 images, no video emulation. No use in betting, games or single club/league/player publications.  /         (Photo credit should read GLYN KIRK/AFP/Getty Images)
Manchester City's Spanish manager Pep Guardiola (L) and Tottenham Hotspur's Argentinian head coach Mauricio Pochettino gesture on the touchline during the English Premier League football match between Tottenham Hotspur and Manchester City at White Hart Lane in London, on October 2, 2016. / AFP / Glyn KIRK / RESTRICTED TO EDITORIAL USE. No use with unauthorized audio, video, data, fixture lists, club/league logos or 'live' services. Online in-match use limited to 75 images, no video emulation. No use in betting, games or single club/league/player publications. / (Photo credit should read GLYN KIRK/AFP/Getty Images)GLYN KIRK/Getty Images

EPL Predictions: Picks, Top Players for Week 22 Premier League Fixtures

Chris LakerJan 16, 2017

Manchester City and Tottenham Hotspur's meeting at the Etihad Stadium on Saturday is the standout match in Week 22 of the Premier League.

Spurs are on a fine run of six league wins in a row and trail leaders Chelsea by seven points. In contrast, City head into the match off the back of a 4-0 defeat away to Everton last weekend and sit fifth in the table.

In other matches, Liverpool play host to Swansea City at Anfield, while Manchester United face a trip to Stoke City.

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United's match represents another chance for them to close the gap on local rivals City. Jose Mourinho's side sit two points behind Pep Guardiola's men in sixth and will be desperate to continue their recent strong run.

Scroll down for an in-depth look at the key players across the weekend, plus all the fixtures and score predictions.

Jan. 2112:30 p.m/7:30 a.mLiverpool vs. Swansea City3-1
Jan. 213 p.m/10 a.mBournemouth vs. Watford1-1
Jan. 213 p.m/10 a.mCrystal Palace vs. Everton1-1
Jan. 213 p.m/10 a.mMiddlesbrough vs. West Ham United3-1
Jan. 213 p.m/10 a.mStoke City vs. Manchester United0-2
Jan. 213 p.m/10 a.mWest Bromwich Albion vs. Sunderland1-1
Jan. 215:30 p.m/12:30 p.mManchester City vs Tottenham Hotspur1-2
Jan. 2212.00 p.m/7 a.mSouthampton vs. Leicester City1-0
Jan. 222:15 p.m/9:15 a.mArsenal vs. Burnley2-0
Jan. 224:30 p.m/11:30 a.mChelsea vs. Hull City4-0

Key men

John Stones

LIVERPOOL, ENGLAND - JANUARY 15: Romelu Lukaku of Everton and John Stones of Manchester City during the Premier League match between Everton and Manchester City at Goodison Park on January 15, 2017 in Liverpool, England. (Photo by Robbie Jay Barratt - AMA

Spurs could look to put defender John Stones under huge pressure, and how well he stands up to the test against in-form Harry Kane could prove vital to City's chances of victory.

While the England centre-back shows glimpses of his much-vaunted potential in bringing the ball out of defence and adding flow to City's attacks, there remain big question marks over Stones' defending ability since his big-money move from Everton.

Mauricio Pochettino's Spurs side are among the best at a pressing game and are likely to target the City back line as a weak spot. If they can isolate Stones, they could enjoy success.

Dele Alli

LONDON, ENGLAND - JANUARY 14: Harry Kane of Tottenham Hotspur (L) celebrates scoring his sides fourth goal with Dele Alli of Tottenham Hotspur (R) during the Premier League match between Tottenham Hotspur and West Bromwich Albion at White Hart Lane on Jan

Tottenham midfielder Dele Alli has been in superb form this season and appears to be improving with every match.

He has been at the forefront of Spurs' attacking play, and his link-up alongside Kane and Christian Eriksen has been integral to the club's surge up the Premier League table to second spot.

There seems to be a newfound maturity to Alli's game, as opposition players have not been able to get under his skin as much as last season. He has subsequently produced more consistent displays, and his impressive goal threat is proving a real asset for the north London side.

Alli is likely to play a key part at the Etihad and will be part of a high-press tactic from Pochettino.

Spurs will aim to close off the supply line to City's midfielders and put pressure on a defence that continues to underperform. It is an issue that Guardiola has shown little signs of addressing and could prove their undoing on Saturday.

Zlatan Ibrahimovic

MANCHESTER, ENGLAND - JANUARY 15:  Zlatan Ibrahimovic of Manchester United gestures during the Premier League match between Manchester United and Liverpool at Old Trafford on January 15, 2017 in Manchester, England.  (Photo by Mike Hewitt/Getty Images)

Zlatan Ibrahimovic has been by far United's main man this season, and his importance cannot be underestimated.

His 14 Premier League goals put him joint top of the goalscoring charts, and he again looks likely to be a key factor as the Red Devils travel to Stoke.

Ibrahimovic's robust, combative style has worked perfectly in England, and his towering presence at the apex of the United attack sees him not only picking up good goalscoring positions, but also bringing others into play with his ability to draw defenders towards him and hold up the ball.

If Stoke are to come away with a positive result on Saturday, then silencing United's talisman is sure to prove vital.

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