Week 10 NFL Picks: Latest Betting Odds, Vegas Spreads and Projections

Week 10 marks the return of the difficult grind for NFL bettors.

It doesn't get much easier than Week 9, in which bettors had to cash on easy favorites such as Dallas, Kansas City and Seattle while also pulling off predictable upsets with Oakland and Detroit. 

On paper, Week 10 is a different animal by comparison. Heavyweight bouts such as Seattle-New England, Dallas-Pittsburgh and Atlanta-Philadelphia headline the slate, with other iffy encounters balancing things out.

To help bettors get an early jump on the lines, here is a full look at the slate.

NFL Week 10 Odds

Matchup	Spread	O/U	Predicted Winner
Cleveland at Baltimore (TNF)	BAL -8	45	BAL 30-13
Houston at Jacksonville	JAC -1	42.5	HOU 28-14
Kansas City at Carolina	CAR -2.5	44	KC 27-20
L.A. Rams at N.Y. Jets	NYJ -2.5	42	LA 20-17
Atlanta at Philadelphia	PHI -1	50.5	ATL 30-27
Green Bay at Tennessee	GB -1	49	GB 24-20
Minnesota at Washington	WAS -1.5	42	MIN 23-20
Chicago at Tampa Bay	TB -2	45	CHI 27-17
Denver at New Orleans	E	49	DEN 26-24
Miami at San Diego	SD -4	49	MIA 27-24
San Francisco at Arizona	ARI -12.5	48.5	ARI 27-14
Dallas at Pittsburgh	PIT -3	50	DAL 28-20
Seattle at New England	NE -9.5	48.5	NE 28-20
Cincinnati at N.Y. Giants (MNF)	NYG -2	47	NYG 27-20

Odds courtesy of Odds Shark.

Cleveland at Baltimore (-8)

This is as easy as it gets for bettors in Week 10, making for one heck of a way to start off the week.

The Cleveland Browns have yet to win a game and don't look poised to do so on Thursday Night Football against the Baltimore Ravens. Crafty bettors will recall Baltimore needed a comeback to secure a 25-20 win against Cleveland in Week 2.

Much has changed since then. Rather than quarterback Josh McCown, Cleveland now leans on Cody Kessler under center. The third-round rookie has thrown five touchdowns to one interception. But the efficiency doesn't mean much when he completes 70.4 percent of his passes with a touchdown in a 35-10 whipping at the hands of the Dallas Cowboys.

Baltimore has been erratic this year but snapped a four-game skid by taking down the Pittsburgh Steelers in Week 9. It was another defensive showdown between the rivals. Baltimore emerged relatively healthy as receiver Mike Wallace boasted four catches for 124 yards and a score.

Painting broad strokes, the Baltimore defense has allowed more than 20 points in a game three times this year. In almost stunning fashion, Cleveland has allowed every opponent faced to score at least 25 points.

On a short week, the better team will slap around the lost team, completing the season sweep.

Prediction: Ravens 30-13

San Francisco at Arizona (-12.5)

This is one of the most interesting (and perhaps difficult) lines of the week because of the gigantic spread.

On one hand, the San Francisco 49ers have lost every game since a Week 1 victory. None has been close, either.

But let's not pretend the Arizona Cardinals have been the shining beacon of consistency. The Cardinals went out in Week 7 and tied with the Seattle Seahawks before taking a 10-point loss to a disappointing Carolina Panthers team.

Even so, remember Week 5? Behind 157 rushing yards and two scores from running back David Johnson, the Cardinals cruised to a 33-21 victory against these 49ers. Call it the perfect remedy to a slump, as the Cardinals had entered that game losers of two in a row.

"We were a hungry team, a team that knows that we dug a hole for ourselves and we had to win this game," Cardinals head coach Bruce Arians said after the game, according to the Associated Press (via ESPN.com).

Speaking of opposing rushers, it's worth digesting a note by ESPN Stats & Info:

There's no saving the 49ers here. There's no using this game's status as a divisional game to justify the 49ers or the under. San Francisco has even tried trotting out Colin Kaepernick under center. For their efforts, the 49ers only posted 23 points against a miserable New Orleans Saints defense in a 41-23 whipping.

As down as the Cardinals might look, Arians' team coming hungry out of a bye makes for an easier bet than it seems.

Prediction: Cardinals 27-14

Dallas at Pittsburgh (-3)

A clash between the Dallas Cowboys and Pittsburgh Steelers will make for one of the more interesting lines to watch all week. 

The end result, though, isn't too difficult to project.

Pittsburgh has now lost three games in a row. One came without Ben Roethlisberger under center, and he wasn't fully healthy last week during the loss to Baltimore. Or at least didn't seem to be. 

Alas, Roethlisberger has gone from throwing three or more touchdowns four times in five games to throwing two touchdowns to three interceptions over his past two games combined. The offense has been grounded, which is bad news against the Cowboys.

Dallas has only lost one game—by a single point—and only two teams have scored 20 or more points against the defense. That defense allows all of 17.5 points per game. Now eight games deep, it's time to kill any stereotypes about it being a weakness.

That said, the offense remains the strength in Dallas. Running back Ezekiel Elliott has 891 yards and seven scores behind one of the league's top offensive lines. Quarterback Dak Prescott has been historic, throwing for 2,020 yards on a 66.5 completion percentage with 12 touchdowns to two interceptions. Again, historic:

Pittsburgh won't have a way to keep pace. The team has scored a high of 16 points over its past three games. Big Ben rushed back in an effort to keep the Steelers afloat in the AFC North, but it's doing more harm than good.

Even if the Dallas defense falters, which it shouldn't, the offense has been smooth enough to compensate. Look for Dallas to keep rolling on the road.

Prediction: Cowboys 28-20

Stats courtesy of NFL.com. All advanced metrics courtesy of Pro Football Focus. 

Follow Chris Roling (@Chris_Roling) on Twitter.