Citing a source, NFL Network's Ian Rapoport confirmed the news.
The Broncos have yet to provide an official timetable for Anderson's recovery, but they could activate him off injured reserve if he's healed at some point during the playoffs.
Rapoport provided additional details regarding Anderson's status:
He added Anderson will be allowed to start jogging again in six weeks and that a meniscus repair was the best option for his long-term health.
Anderson posted a message on Twitter regarding his timetable:
Following a 2015 season full of inconsistencies, Anderson put together a strong first seven weeks in 2016 as the Broncos embarked on their Super Bowl title defense.
Over the first two months of the season, Anderson rushed for 437 yards and four touchdowns while catching 16 passes for 128 yards and a score.
Now that it appears Anderson will miss the remainder of the regular season at least, rookie Devontae Booker is in line for primary rushing responsibilities in the backfield.
In his first NFL season out of Utah, the No. 136 overall pick has provided value. In a 51-carry sample, the 24-year-old has rushed for 244 yards and one touchdown, averaging 4.8 yards per carry. He's also proved effective in the passing game with nine catches for 69 yards on 13 targets.
"I think [Booker]...is becoming more comfortable with what we're doing," head coach Gary Kubiak said, per Pro Football Talk's Mike Florio. "We're more comfortable with [Booker] on the field in pass protection right now. We’re just growing as a group. Here we go in Week 8 and hopeful those kids keep coming along. It's going to make us better if they do."
Based on the way Booker has performed to this point in the season, the Broncos offense should keep chugging along. The reigning champions face the 3-4 San Diego Chargers on Sunday.