College Football Week 13 Odds: Ohio State, Alabama, Notre Dame Betting Favorites

Coming off an upset loss to the Michigan State Spartans, the Ohio State Buckeyes will be looking to regroup Saturday afternoon when they face the Michigan Wolverines as 2.5-point road favorites on the opening odds at sportsbooks monitored by Odds Shark.

The Buckeyes were handed a 17-14 home loss by the Spartans over the weekend, dropping them to 10-1 straight up and 4-7 against the spread on the season and putting a huge dent in their chances of making the College Football Playoff. Ezekiel Elliott rushed for just 33 yards and one touchdown for Ohio State in the losing cause.

Michigan is 9-2 straight up and 6-5 ATS on the season. The Wolverines are 0-3 straight up in their last three games against the Buckeyes, according to the Odds Shark college football database, and 1-9 straight up in the last 10 meetings between the schools dating back to 2005. However, the Wolverines have gone 2-0 ATS in the last two games between the teams.

Michigan State, meanwhile, will face the Penn State Nittany Lions this week while looking to wrap up the Big Ten East Division title; like the Buckeyes, the Spartans are 10-1 straight up and 4-7 ATS on the season. No opening line is available yet for the Michigan State-Penn State matchup because of the uncertain status of Spartans quarterback Connor Cook, who missed last week's game after suffering a shoulder injury.

Elsewhere, the Clemson Tigers, sitting atop the Associated Press Top 25, opened as 15.5-point road favorites against the South Carolina Gamecocks, while the Alabama Crimson Tide opened as 13-point road favorites against the Auburn Tigers for their Iron Bowl matchup. Alabama is 3-1 both straight up and ATS in its last four games against Auburn, beating the Tigers 55-44 last year while just managing to cover the 9.5-point spread at home.

Other rivalry matchups for the week saw the Oregon Ducks open as 30-point home favorites against the Oregon State Beavers, the Southern Cal Trojans open as 3.5-point home favorites against the UCLA Bruins, the North Carolina Tar Heels open as six-point road favorites against the North Carolina State Wolfpack, the Georgia Bulldogs open as 4.5-point road favorites against the Georgia Tech Yellow Jackets and the Florida Gators open as three-point home favorites against the Florida State Seminoles.

The Ole Miss Rebels opened as two-point road favorites against the Mississippi State Bulldogs, while the Notre Dame Fighting Irish opened as two-point road favorites against the Stanford Cardinal. The Fighting Irish edged the Cardinal 17-14 as three-point home underdogs when the schools met last season, and Notre Dame is 7-2 ATS in its last nine road games against Stanford.

In the Big 12, Friday's TCU-Baylor matchup opened as a pick 'em, while the Oklahoma Sooners opened as 3.5-point road favorites against the Oklahoma State Cowboys. The Cowboys knocked off the Sooners 38-35 as big 19.5-point road underdogs last season, with Oklahoma State covering the spread in three of its last four games against Oklahoma.