NFL Week 10 Picks: Latest Predictions for Updated Spreads

The best NFL bettors on a week-to-week basis act something akin to the NFL's most patient, explosive running backs.

Those sort of running backs, perhaps best personified by Pittsburgh's Le'Veon Bell, wait behind the line almost to a fault before exploding through the developing hole. It works, but it's certainly not something the majority can pull off.

Bettors can take this approach to spreads out of Las Vegas, though, by tackling midweek lines. There, the early verdicts from oddsmakers have shifted based on updated news and countless bets, giving bettors an idea as to where things are going and how and when to strike.

Below, let's take a look at the updated spreads and point out how bettors should hit the holes before they close late in the week.

NFL Week 10 Odds

Game	Spread	O/U	Predicted Winner
Buffalo at New York Jets	NYJ -2.5	42.5	NYJ 27-24
Jacksonville at Baltimore	BAL -5.5	48	JAC 21-20
Detroit at Green Bay	GB -13	47.5	GB 30-17
Miami at Philadelphia	PHI -7	46.5	PHI 28-25
Cleveland at Pittsburgh	PIT -4.5	41	PIT 14-13
Chicago at St. Louis	STL -7.5	42.5	STL 20-16
Dallas at Tampa Bay	TB -1	43	DAL 23-20
Carolina at Tennessee	CAR -5	43.5	CAR 27-20
New Orleans at Washington	E	50.5	NO 20-17
Minnesota at Oakland	NL	N/A	OAK 23-20
Kansas City at Denver	DEN -7	41.5	DEN 23-14
New England at New York Giants	NE -8.5	54.5	NE 33-20
Arizona at Seattle	SEA -3	44.5	ARI 17-10
Houston at Cincinnati	CIN -12	47	CIN 27-20

Odds courtesy of Odds Shark.    

Midweek Odds to Bet

Carolina (-4.5) at Tennessee

It won't be long before this becomes a full touchdown or more, so hop on board. 

This line almost seems an overreaction because the Tennessee Titans were able to pull off an upset of the New Orleans Saints in Week 9, but it glosses over the fact that before that, the 2-6 Titans hadn't won since Week 1.

All the Carolina Panthers do is win, and they happen to have a win over those Saints, too.

For one reason or another, Carolina continues to fly a tad under the radar, expected most weeks to finally take a loss. Except it didn't happen against Philadelphia (27-16), Indianapolis (29-26) or especially against Green Bay last weekend (37-29).

In fact, the Panthers have allowed more than 20 points just five times this year. Cam Newton's easily one of the top MVP candidates with his 14 touchdowns to nine interceptions with another 343 yards and five scores on the ground.

The Tennessee defense, which let up 28 points to Cleveland, 35 to Indianapolis and even 38 to Miami, won't have an answer for Newton. Look for the Panthers to stay undefeated by at least a touchdown.

Prediction: Panthers 27, Titans 20

Kansas City at Denver (-7)

Here's another line sure to see some adjustment bettors may want to grab before it moves. 

The Kansas City Chiefs might be winners of two in a row, but sitting at 3-5 with wins against a Ben Roethlisberger-less Pittsburgh Steelers team and a 1-7 Detroit Lions squad isn't anything to write home about.

Neither is Peyton Manning and the Denver Broncos taking a loss in Indianapolis last week, bringing them to 7-1.

In fact, little has changed between these two since their Week 2 meeting in Kansas City, where the visitors took the 31-24 decision behind three touchdowns from Manning to counteract 125 rushing yards and a score by Jamaal Charles.

Now, though, this one goes down in Denver, and perhaps the biggest change is the absence of Charles. Even with the star running back, Kansas City let up four sacks of Alex Smith, who also threw a pair of interceptions.

Kansas City has won just a single game on the road this year. The leaky defense won't be able to slow Manning at home, and Smith getting forced into a one-dimensional attack against an elite unit all too familiar with him is nothing short of bad news.

Manning won't have any problems putting away the Chiefs to complete the season sweep.

Prediction: Broncos 23, Chiefs 14

Arizona at Seattle (-3)

Jeff Haynes/Associated Press

An encounter between the Arizona Cardinals and Seattle Seahawks with both teams coming out of a bye writes itself.

To write it, though, one has to scribble just one sentence: Seattle doesn't have the offense to keep pace with Arizona.

The Cardinals average 32.9 points per game, second only to New England. Not only has Carson Palmer completed 64.6 percent of his passes with 20 scores to six picks, Chris Johnson behind him has revived his career with 676 yards and three scores.

Seattle averages just 20.9 points per game and mustered 20 against San Francisco in Week 7, then 13 in Week 8 against Dallas, the latter to squeak to an iffy 4-4 record.

"I thought the defense was lights out tonight, making big plays for us," Seahawks quarterback Russell Wilson said, per ESPN.com. "On offense, when we needed it, we converted and made plays, like the last drive."

In theory, this will be a defensive battle, as both units let up less than 20 points per game. But it's Seattle's unit, even at home, that has faltered in the face of elite competition, letting up at least 27 points four times.

There's just enough leeway there for Palmer and Co. to take advantage in a low-scoring affair while keeping the Seahawks at an arm's length.

Prediction: Cardinals 17, Seahawks 10

Stats courtesy of NFL.com and accurate as of Nov. 10. All advanced metrics courtesy of Pro Football Focus.