College Football Week 2 Odds: Betting Highlights for Oregon vs. MSU and More

The biggest matchup on the Week 2 college football betting slate is too close to call, at least according to sportsbooks monitored by Odds Shark, as the Michigan State Spartans play host to the Oregon Ducks at Spartan Stadium on Saturday night.

The sportsbooks opened the Ducks vs. Spartans betting matchup as a pick 'em Sunday afternoon, although early wagering did push Michigan State to a three-point favorite.

Michigan State, No. 5 in the Associated Press Top 25 in Week 1, beat the Western Michigan Broncos 37-24 as a 16-point favorite in its opener. Oregon, No. 7 in the AP Top 25 in Week 1, is coming off a 61-42 win over the Eastern Washington Eagles as a 35-point favorite.

Michigan State lost 46-27 as a 14-point road underdog against Oregon last September.

The Notre Dame Fighting Irish opened as 11.5-point favorites on the road against the Virginia Cavaliers for Week 2 at the sportsbooks, with that line slipping a bit to make the Irish 10.5-point chalk by late Sunday. Notre Dame beat Texas 38-3 as a nine-point favorite in Week 1 but announced Sunday that running back Tarean Folston suffered a season-ending knee injury.

Former Notre Dame quarterback Everett Golson led his new team, the Florida State Seminoles, to a 59-16 rout of the Texas State Bobcats in Week 1, with the quarterback throwing for 302 yards and four touchdowns in the contest. The Seminoles opened as big 29-point home favorites for their Saturday matchup against the South Florida Bulls at Doak Campbell Stadium.

The Oklahoma Sooners and the LSU Tigers both opened as slim three-point road favorites for their Saturday games, with Oklahoma facing the Tennessee Volunteers and LSU going up against the Mississippi State Bulldogs. The BYU Cougars, meanwhile, opened as 1.5-point home underdogs against the Boise State Broncos after they lost quarterback Taysom Hill to a season-ending foot injury over the weekend.

The Utah Utes opened as 11-point home favorites against the rival Utah State Aggies for their Friday night matchup, while bigger favorites on the early lines for Week 2 include the Wisconsin Badgers as 33-point chalk at home against the Miami (Ohio) RedHawks and the Alabama Crimson Tide as 34-point chalk at home against the Middle Tennessee Blue Raiders.

And the top-ranked Ohio State Buckeyes don't get their season started until Monday night against the Virginia Tech Hokies, but they opened as huge 38-point home favorites for their Week 2 matchup against the Hawaii Rainbow Warriors this weekend at the sportsbooks. Ohio State is a 14-point favorite against Virginia Tech.